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Human Polyoma virus (JC) belongs to the genus Polyomavirus. JC is capable of transforming fetal brain cells and human amnion cells in vitro and can lead to tumor development in other species. JC VP1 (gp01) is one of the three constituent capsid proteins produced by the JC virion. JC also contains the capsid proteins VP2 (gp02) and VP3 (gp03), as well as a viral minichromosome. VP1 is the primary capsid protein, comprising 75% of the total capsid shell protein. It is thought that the tumor inducing properties of JC may be credited to an interaction between VP1, cellular retinoblastoma protein and p53. In immunocompromised individuals, JC has been known to cause progressive multifocal leukoencephalopathy (PML). About 10% of the capsid proteins are made from VP2 and VP3.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Polyoma virus VP1 (2E4) | sc-65930 | 100 µg/ml | $316.00 |