(+/-)14(15)-EET Ethanolamide MF: C22H37NO3
MW: 363.5
An endogenous lipid neurotransmitter with cannabinergic activity.

(±)14(15)-EET Ethanolamide

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Application: (±)14(15)-EET Ethanolamide is an endogenous lipid neurotransmitter with cannabinergic activity
Masse Moléculaire: 363.5
Formule Moléculaire: C22H37NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

An endogenous lipid neurotransmitter with cannabinergic activity, binding to both the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the hydrolysis and inactivation of AEA. Metabolism of AEA by cyclooxygenase-2, leading to formation of prostaglandin ethanolamides and by lipoxygenases has also been documented. (±)14(15)-EET ethanolamide is a potential cytochrome P450 (CYP450) metabolite of AEA, although specific stereochemistry rather than a racemic mixture would likely ensue from enzymatic metabolism. CYP450 metabolism of AEA may be particularly relevant under conditions of FAAH inhibition. Evidence for the formation of (±)14(15)-EET ethanolamide in vivo has not been documented.


Références

1. Felder, C.C., et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 7656-7660. PMID: 8395053
2. Lambert, D.M. and Fowler, C.J. 2005. J. Med. Chem. 48: 5059-5087. PMID: 16078824
3. Kozak, K.R., et al. 2002. J Biol Chem. 277: 44877-44885. PMID: 12244105
4. Deutsch, D.G., et al. 2002. Prostaglandins Leukot Essent Fatty Acids. 66: 201-210. PMID: 12052036

Formulation :
A solution in ethanol
État Physique :
Liquid
STOCKAGE :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Télécharger la Fiche de Sécurité/ SDS (MSDS)

CERTIFICAT D'ANALYSE

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