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Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 3 (PKP3) is a 797 amino acid protein that contains eight arm-repeats and belongs to the beta-catenin family. Encoded by a gene that maps to human chromosome 11p15.5, plakophilin 3 localizes to desmosomes of most simple and nearly all stratified epithelia, as well as cell lines derived therefrom, with the exception of hepatocytes and hepatocellular carcinoma cells. Plakophilin 3 plays a role in both desmosome-dependent adhesion and signaling pathways, and may play a role in junctional plaques. Up-regulation of plakophilin 3 is a frequent and important feature of lung carcinogenesis, implicating plakophilin 3 as a candidate prognostic marker and therapeutic target for lung cancer.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps plakophilin 3 (12B11F8) | sc-59977 | 200 µg/ml | $316.00 | |||
plakophilin 3 (12B11F8): m-IgG Fc BP-HRP Kit | sc-539155 | 200 µg Ab; 10 µg BP | $354.00 |