Date published: 2025-9-11

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Anticorps plakophilin 3 (12B11F8): sc-59977

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Fiches techniques
  • L'Anticorps plakophilin 3 (12B11F8) est un monoclonal de souris IgG2a (chaîne légère kappa) fourni en 200 µg/ml
  • dirigé contre les acides aminés 779-793 de plakophilin 3 d'origine human
  • recommandé pour la détection de plakophilin 3 d'origine mouse, rat, human, Xenopus et canine par WB, IP et IF; non cross-reactif avec any other plakophilin or armadillo protein
  • Le m-IgG Fc BP-HRP est le réactif de détection secondaire préféré pour l'anticorps plakophilin 3 (12B11F8) pour les applications WB. Ce réactif est désormais proposé en bundle avec l'anticorps plakophilin 3 (12B11F8)(voir les informations de commande ci-dessous).

    ACCÈS RAPIDE AUX LIENS

    VOIR ÉGALEMENT...

    Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 3 (PKP3) is a 797 amino acid protein that contains eight arm-repeats and belongs to the beta-catenin family. Encoded by a gene that maps to human chromosome 11p15.5, plakophilin 3 localizes to desmosomes of most simple and nearly all stratified epithelia, as well as cell lines derived therefrom, with the exception of hepatocytes and hepatocellular carcinoma cells. Plakophilin 3 plays a role in both desmosome-dependent adhesion and signaling pathways, and may play a role in junctional plaques. Up-regulation of plakophilin 3 is a frequent and important feature of lung carcinogenesis, implicating plakophilin 3 as a candidate prognostic marker and therapeutic target for lung cancer.

    Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

    Informations pour la commande

    Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

    Anticorps plakophilin 3 (12B11F8)

    sc-59977
    200 µg/ml
    $316.00

    plakophilin 3 (12B11F8): m-IgG Fc BP-HRP Kit

    sc-539155
    200 µg Ab; 10 µg BP
    $354.00

    For Western Blot, is it recommended to use denatured or non-denatured conditions with plakophilin 3 (12B11F8): sc-59977 monoclonal antibody?

    Posée par: Randy McDonald
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Répondue par: Technical Support
    Date de publication: 2017-02-27
    • y_2025, m_9, d_10, h_9CST
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    Rated 4 de 5 de par Worked well with transfected lysate by WBWorked well with transfected lysate by WB. -SCBT QC
    Date de publication: 2015-06-11
    Rated 4 de 5 de par Nice bands seen in WB using HeLaNice bands seen in WB using HeLa, A549 and Caco-2 whole cell lysates. -SCBT QC
    Date de publication: 2013-12-11
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    Anticorps plakophilin 3 (12B11F8) est évalué 4.0 de 5 de 2.
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