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Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 3 plays a role in both desmosome-dependent adhesion and signaling pathways. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps plakophilin 1 (3G250) | sc-71900 | 200 µg/ml | $316.00 | |||
plakophilin 1 (3G250): m-IgG Fc BP-HRP Kit | sc-539420 | 200 µg Ab; 10 µg BP | $354.00 | |||
plakophilin 1 (3G250): m-IgG1 BP-HRP Kit | sc-541480 | 200 µg Ab; 20 µg BP | $354.00 |