PIPK I α Antibody (F-4): sc-398687
- PIPK I α Antibody (F-4) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 27-59 near the N-terminus of PIPK I α of human origin
- recommended for detection of PIPK I α of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PIPK I α Antibody (F-4) for WB applications. These reagents are now offered in bundles with PIPK I α Antibody (F-4) (see ordering information below).
PIPK I α Antibody (F-4) is a mouse monoclonal IgG1 antibody that detects phosphatidylinositol-4-phosphate-5-kinase I α in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PIPK I α plays a crucial role in synthesizing phosphatidylinositol-4,5-bisphosphate, a key lipid that regulates various cellular processes, including cell proliferation, survival, membrane trafficking, and cytoskeletal organization. PIPK I α monoclonal antibody (F-4) recognizes a protein involved in signaling pathways that govern cellular responses to external stimuli, making PIPK I α vital for maintaining cellular homeostasis and function. PIPK I α is predominantly expressed in brain tissue, where PIPK I α contributes to neuronal signaling and synaptic function. Additionally, PIPK I α is part of a larger family of phosphatidylinositol-4-phosphate-5-kinases, which are categorized into type I, type II, and type III, each with distinct substrate specificity and regulatory mechanisms. The unique activation loop present in these kinases is essential for their enzymatic activity and subcellular localization, further emphasizing the significance of PIPK I α in cellular dynamics. Anti-PIPK I α antibody (F-4) serves as an invaluable tool for researchers studying the intricate roles of PIPK I α in human health and disease.
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PIPK I α Antibody (F-4) References:
- Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization. | Xie, Y., et al. 2000. Cytogenet Cell Genet. 88: 197-9. PMID: 10828584
- Amplification of Chromosome 1q Genes Encoding the Phosphoinositide Signalling Enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in Breast Cancer. | Waugh, MG. 2014. J Cancer. 5: 790-6. PMID: 25368680
- LPS-induced clustering of CD14 triggers generation of PI(4,5)P2. | Płóciennikowska, A., et al. 2015. J Cell Sci. 128: 4096-111. PMID: 26446256
- Spatiotemporal Control of Lipid Conversion, Actin-Based Mechanical Forces, and Curvature Sensors during Clathrin/AP-1-Coated Vesicle Biogenesis. | Anitei, M., et al. 2017. Cell Rep. 20: 2087-2099. PMID: 28854360
- Apical PtdIns(4,5)P2 is required for ciliogenesis and suppression of polycystic kidney disease. | Xu, W., et al. 2019. FASEB J. 33: 2848-2857. PMID: 30321068
- Comprehensive genomic profiling identifies novel NTRK fusions in neuroendocrine tumors. | Sigal, DS., et al. 2018. Oncotarget. 9: 35809-35812. PMID: 30533196
- Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway. | Sun, L., et al. 2021. Bioengineered. 12: 7104-7118. PMID: 34546850
- Circular RNA PIP5K1A act as microRNA-552-3p sponge to regulates inflammation, oxidative damage in glucolipotoxicity-induced pancreatic INS-1 β-cells via Janus kinase 1. | Ren, L. 2022. Bioengineered. 13: 5724-5736. PMID: 35184688
- Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling. | Yu, X., et al. 2022. Proc Natl Acad Sci U S A. 119: e2210618119. PMID: 36322759
- Omics Analyses in a Neural Stem Cell Model of Familial Parkinson's Disease. | Notopoulou, S., et al. 2023. Adv Exp Med Biol. 1423: 149-160. PMID: 37525039
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PIPK I α Antibody (F-4) | sc-398687 | 200 µg/ml | $322.00 | |||
PIPK I α Antibody (F-4): m-IgG Fc BP-HRP Bundle | sc-538502 | 200 µg Ab; 10 µg BP | $361.00 | |||
PIPK I α Antibody (F-4): m-IgGκ BP-HRP Bundle | sc-536128 | 200 µg Ab; 40 µg BP | $361.00 | |||
PIPK I α Antibody (F-4): m-IgG1 BP-HRP Bundle | sc-545735 | 200 µg Ab; 20 µg BP | $361.00 | |||
PIPK I α (F-4) Neutralizing Peptide | sc-398687 P | 100 µg/0.5 ml | $69.00 |