PIPK I alpha Antibody (D-4): sc-515416

PIPK I α Antibody (D-4) is a mouse monoclonal IgG2a antibody that detects phosphatidylinositol-4-phosphate-5-kinase I α (PIPK I α) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PIPK I α plays a crucial role in synthesizing phosphatidylinositol-4,5-bisphosphate, a lipid essential for various cellular processes, including cell proliferation, survival, and membrane trafficking. PIPK I α (D-4) antibody helps researchers study cytoskeletal organization, which is vital for maintaining cell shape and facilitating movement. PIPK I α belongs to the PIPK family, which is categorized into three types, each with distinct substrate specificity and cellular localization due to the presence of an activation loop that governs enzymatic activity. PIPK I α is expressed in brain tissue and phosphorylates phosphatidylinositol-4-phosphate at the 5-hydroxyl position, thereby influencing signaling pathways that regulate cellular functions. Anti-PIPK I α antibody (D-4) enables researchers to explore PIPK I α′s role in neurobiology and neurological disorders, making PIPK I α (D-4) monoclonal antibody an invaluable tool for studying human health and disease.

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PIPK I alpha Antibody (D-4) References:

1. Positive selection for the male functionality of a co-retroposed gene in the hominoids.  |  Zhang, Y., et al. 2009. BMC Evol Biol. 9: 252. PMID: 19832993
2. Inference for the initial stage of domain shuffling: tracing the evolutionary fate of the PIPSL retrogene in hominoids.  |  Ohshima, K. and Igarashi, K. 2010. Mol Biol Evol. 27: 2522-33. PMID: 20525901
3. The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor.  |  Sarwar, M., et al. 2019. Oncogene. 38: 375-389. PMID: 30104711
4. Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.  |  Noch, EK., et al. 2021. J Comp Neurol. 529: 434-449. PMID: 32449185
5. Study and detection of potential markers for predicting metastasis into lymph nodes in prostate cancer.  |  Papasotiriou, I., et al. 2020. Biomark Med. 14: 1317-1327. PMID: 32799659
6. Establishing a Urine-Based Biomarker Assay for Prostate Cancer Risk Stratification.  |  Guo, J., et al. 2020. Front Cell Dev Biol. 8: 597961. PMID: 33363151
7. An epigenomic landscape of cervical intraepithelial neoplasia and cervical cancer using single-base resolution methylome and hydroxymethylome.  |  Han, Y., et al. 2021. Clin Transl Med. 11: e498. PMID: 34323415
8. The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation.  |  Ding, T., et al. 2023. Cell Res. 33: 617-627. PMID: 37142675
9. Bioinformatic-Experimental Screening Uncovers Multiple Targets for Increase of MHC-I Expression through Activating the Interferon Response in Breast Cancer.  |  Li, X., et al. 2024. Int J Mol Sci. 25: PMID: 39408874
10. Frequent copy number gain of MCL1 is a therapeutic target for osteosarcoma.  |  Takagi, S., et al. 2024. Oncogene.. PMID: 39663392

The preferred PIPK I antibody is PIPK I Antibody (D-12): sc-365238.