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PELO (pelota homolog), also known as CGI-17 or PRO1770, is a 385 amino acid nuclear and cytoplasmic protein that belongs to the eukaryotic release factor 1 family and the pelota subfamily. Evolutionary conserved, PELO may be involved in the regulation of cell proliferation and stem cell self-renewal, and is suggested to be required for normal chromosome segregation during cell division and genomic stability. PELO may possess ribonuclease activity and has the ability to recognize stalled ribosomes, thereby triggering endonucleolytic cleavage of mRNA, a mechanism that releases non-functional ribosomes and degrades damaged mRNAs. PELO is ubiquitously expressed and utilizes divalent metal cations as cofactors. PELO may be essential for spermatogenesis, cell cycle control and in meiotic cell division. PELO is encoded by a gene located on human chromosome 5q11.2.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PELO (F-8) | sc-393448 | 200 µg/ml | $316.00 | |||
PELO (F-8): m-IgG Fc BP-HRP Kit | sc-538220 | 200 µg Ab; 10 µg BP | $354.00 | |||
PELO (F-8): m-IgGκ BP-HRP Kit | sc-535788 | 200 µg Ab; 40 µg BP | $354.00 | |||
PELO (F-8): m-IgG1 BP-HRP Kit | sc-545585 | 200 µg Ab; 20 µg BP | $354.00 |