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Oxidoreductase-protein disulfide isomerase (PDI) is a homodimer consisting of subunits that catalyzes thiol-disulfide exchange, mediates folding of newly synthesized proteins and functions as a molecular chaperone. PDI localizes to the lumen of the endoplasmic reticulum (ER), where in conjunction with folding-helper proteins, such as immunoglobulin heavy chain binding protein (BiP), mediates tertiary and quaternary protein-processing. Cell surface PDI induces sulfhydryl-mediated conformational changes in integrin-mediated adhesion receptor-ligand interactions, thereby regulating integrin responses and cell adhesion. Additionally, PDI functions as a subunit of two more complex enzyme systems: the prolyl-4-hydroxylase and the triacylglycerol transfer proteins.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PDI (A-1) | sc-376370 | 200 µg/ml | $316.00 | |||
PDI (A-1): m-IgG Fc BP-HRP Kit | sc-540555 | 200 µg Ab; 10 µg BP | $354.00 | |||
PDI (A-1): m-IgG1 BP-HRP Kit | sc-542203 | 200 µg Ab; 20 µg BP | $354.00 | |||
PDI (A-1) peptide neutralisant | sc-376370 P | 100 µg/0.5 ml | $68.00 |