PCDHA11 Antibody (A-4): sc-514668

PCDHA11 Antibody (A-4) is a mouse monoclonal IgM antibody that detects PCDHA11 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PCDHA11 antibody (A-4) is available as the non-conjugated form. Protocadherins, including PCDHA11, are crucial for the establishment and maintenance of neuronal connections in the brain, and belong to a large family of cadherin-like cell adhesion proteins. The PCDH-alpha gene cluster, which includes PCDHA11, contains multiple genes that encode proteins involved in cell adhesion processes. PCDHA11 is a 949 amino acid single-pass transmembrane protein characterized by six cadherin domains, and functions as a potential calcium-dependent cell-adhesion protein, playing a significant role in the formation and maintenance of synaptic connections. PCDHA11 interacts with Integrin β1, which enhances cell adhesion and facilitates the formation of oligomers with PCDH-gamma proteins at specific membrane sites, underscoring its importance in neuronal connectivity. PCDHA11 is subject to alternative splicing, resulting in two isoforms that may have distinct functional roles in cellular processes.

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PCDHA11 Antibody (A-4) References:

1. Promoter choice determines splice site selection in protocadherin alpha and gamma pre-mRNA splicing.  |  Tasic, B., et al. 2002. Mol Cell. 10: 21-33. PMID: 12150904
2. The role and expression of the protocadherin-alpha clusters in the CNS.  |  Hirayama, T. and Yagi, T. 2006. Curr Opin Neurobiol. 16: 336-42. PMID: 16697637
3. Allelic gene regulation of Pcdh-alpha and Pcdh-gamma clusters involving both monoallelic and biallelic expression in single Purkinje cells.  |  Kaneko, R., et al. 2006. J Biol Chem. 281: 30551-60. PMID: 16893882
4. Identification of long-range regulatory elements in the protocadherin-alpha gene cluster.  |  Ribich, S., et al. 2006. Proc Natl Acad Sci U S A. 103: 19719-24. PMID: 17172445
5. Combinatorial expression of alpha- and gamma-protocadherins alters their presenilin-dependent processing.  |  Bonn, S., et al. 2007. Mol Cell Biol. 27: 4121-32. PMID: 17403907
6. Relationship between DNA methylation states and transcription of individual isoforms encoded by the protocadherin-alpha gene cluster.  |  Kawaguchi, M., et al. 2008. J Biol Chem. 283: 12064-75. PMID: 18204046
7. Clustered protocadherin family.  |  Yagi, T. 2008. Dev Growth Differ. 50 Suppl 1: S131-40. PMID: 18430161

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PCDHA11 Antibody (A-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PCDHA11 Antibody (A-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PCDHA11 Antibody (A-4) Specifications

Alternate Product Name: PCDHA11

Product Clone Name: A-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 281-299

Epitope Target: PCDHA11

Epitope Species: mouse

Product Reactivity/Detection: PCDHA11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PCDHA11 Antibody (A-4): P: Blocking Peptide