Poly(ADP-ribose) polymerase-1 (PARP-1), also designated PARP, is a nuclear DNA-binding, zinc finger protein that influences DNA repair, DNA replication, modulation of chromatin structure and apoptosis. In response to genotoxic stress, PARP-1 catalyzes the transfer of ADP-ribose units from NAD+ to a number of acceptor molecules, including chromatin. PARP-1 recognizes DNA strand interruptions, can complex with RNA, and negatively regulates transcription. Actinomycin D- and etoposide-dependent induction of caspases mediates cleavage of PARP-1 into a p89 fragment that traverses into the cytoplasm. PARP-10 is a PARP enzyme that is involved in the control of cell proliferation. PARP-10 localizes to the nuclear and cytoplasmic compartments, where it inhibits c-Myc- and E1A-mediated fibroblast cotransformation.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps PARP-10 (6D643) | sc-71851 | 200 µg/ml | $316.00 |