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Pancreatic Polypeptide (PP) and Pancreatic Icosapeptide (PI) are both deduced from the pancreatic prohormone precursor. The two peptide sequences are seperated by a Gly-Lys-Arg cleavage and amidation site. The Pancreatic Polypeptide lies on the N-terminal side of this cleavage site while the Pancreatic Icosapeptide lies on the C-terminal side. The prohormone precursor is produced by the endocrine F-cells of the pancreatic islets and, in response to food intake, the Pancreatic Polypeptide is released into the circulation. The Pancreatic Polypeptide is a member of the neuropeptide Y (NPY) family of hormones that bind to Y receptors. In particular, it binds to Y4 receptors and functions as an anorexigenic hormone. Subjects with Prader-Willi syndrome have a decreased Pancreatic Polypeptide response to a meal. Administration of Pancreatic Polypeptide decreases food intake and may serve as a therapeutic option for treatment of obesity.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Pancreatic Polypeptide (030-06-1) | sc-80494 | 100 µg/ml | $316.00 |