Anticorps Paip2 (A-2): sc-376970

Paip, for PABP-interacting protein, binds to the polyadenylate-binding protein (PABP). There are two Paip proteins called Paip1 and Paip2. Paip1 stimulates translation, and Paip2, which competes with Paip1 for binding to PABP, represses translation. Paip1 contains a region similar to the central portion of eIF4G. Paip2 decreases the affinity of PABP for polyadenylate RNA, and disrupts the repeating structure of poly(A) ribonucleoprotein. Paip2 contains two binding sites for PABP, one encompassing a 16 amino-acid stretch located in the C terminus and a second encompassing a larger central region. There is a two-to-one stoichiometry for binding of Paip2 to PABP indicating that they could form a trimeric complex containing one PABP molecule and two Paip2 molecules. Significantly, only the central Paip2 fragment, which binds with high affinity to the PABP RRM region, inhibits PABP binding to poly(A) RNA and translation. Translation in extracts in which elF4G is cleaved is resistant to inhibition by Paip2. The human Paip2 gene maps to chromosome 5q31 and encodes a 127 amino acid protein.

L'anticorps Paip2 préféré est l'Anticorps Paip2 (C-8): sc-365317.