p53 Antibody (C-11): sc-74574
- p53 Antibody (C-11) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 186-385 of p53 of Drosophila melanogaster origin
- recommended for detection of p53 of d origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for p53 Antibody (C-11) for WB applications. These reagents are now offered in bundles with p53 Antibody (C-11) (see ordering information below).
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p53 Antibody (C-11) is a non-mammalian monoclonal IgG2a kappa light chain antibody, raised against amino acids 186-385 of p53 from Drosophila melanogaster origin, exhibiting species reactivity specifically with Drosophila melanogaster. The p53 protein in Drosophila melanogaster, known as Dmp53, is a pivotal transcription factor that plays a crucial role in regulating apoptosis and maintaining genomic stability in response to DNA damage and cellular stress. Dmp53 activates the expression of pro-apoptotic genes such as Reaper, Hid, and Grim, which are essential for initiating programmed cell death and preventing the accumulation of damaged or mutated cells. This function is vital for normal development and for safeguarding the organism against genomic instability. Dmp53 is regulated by phosphorylation through kinases like ATM and ATR, which detect DNA damage and activate Dmp53′s transcriptional activity, leading to appropriate cellular responses to genotoxic stress. Interactions between Dmp53 and these kinases are critical for the DNA damage response pathway, ensuring that cells with DNA damage either repair the damage or undergo apoptosis. Dysregulation or mutations in Dmp53 can result in developmental abnormalities and increased sensitivity to DNA-damaging agents. p53 monoclonal antibody (C-11) is suitable for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA), making p53 (C-11) antibody an invaluable tool for researchers studying the role of Dmp53 in apoptosis, DNA damage response, and its interactions with key regulatory proteins in Drosophila melanogaster.
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p53 Antibody (C-11) References:
- A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. | Lunardi, A., et al. 2010. Proc Natl Acad Sci U S A. 107: 6322-7. PMID: 20308539
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p53 Antibody (C-11) | sc-74574 | 200 µg/ml | $322.00 | |||
p53 Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-539550 | 200 µg Ab; 10 µg BP | $361.00 | |||
p53 Antibody (C-11): m-IgG2a BP-HRP Bundle | sc-546733 | 200 µg Ab; 10 µg BP | $361.00 |