OX2 Antibody (1.BB.648): sc-71762
- OX2 Antibody (1.BB.648) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against full length CD200 of rat origin
- recommended for detection of a monomorphic determinant of OX2 of mouse and rat origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for OX2 Antibody (1.BB.648). These reagents are now offered in bundles with OX2 Antibody (1.BB.648) (see ordering information below).
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OX2 Antibody (1.BB.648) is a mouse monoclonal IgG1 antibody that detects OX2 in mouse and rat samples through immunofluorescence (IF) and flow cytometry (FCM) applications. OX2, also known as CD200, is a 248-residue cell surface glycoprotein belonging to the immunoglobulin superfamily, primarily expressed in lymphoid cells, neurons, and endothelial tissues. OX2 monoclonal antibody (1.BB.648) recognizes a protein that interacts with OX2R, which is predominantly found in lymphoid and neuronal tissues. This interaction is crucial as OX2 may help regulate pathways that suppress macrophage-induced inflammatory damage, thereby maintaining tissue homeostasis. Notably, OX2R is characterized by a cytoplasmic domain containing NPXY motifs that facilitate binding to phosphotyrosine-binding (PTB) domains, further underscoring the importance of this signaling pathway in immune regulation. With a high degree of N-linked glycosylation, accounting for up to 70% of its weight, OX2R′s structure is essential for function and interaction with OX2, making anti-OX2 antibody (1.BB.648) a valuable tool for researchers studying immune modulation and inflammation in various biological contexts.
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OX2 Antibody (1.BB.648) References:
- CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease. | Wang, XJ., et al. 2007. J Neuroimmune Pharmacol. 2: 259-64. PMID: 18040859
- Analysis of the Impact of CD200 on Phagocytosis. | Lyons, A., et al. 2017. Mol Neurobiol. 54: 5730-5739. PMID: 27830533
- CD200-, CX3CL1-, and TREM2-mediated neuron-microglia interactions and their involvements in Alzheimer's disease. | Zhang, L., et al. 2018. Rev Neurosci. 29: 837-848. PMID: 29729150
- CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke. | Zhao, SC., et al. 2020. Brain Behav. 10: e01882. PMID: 33067924
- CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. | Kassiteridi, C., et al. 2021. Circ Res. 129: 280-295. PMID: 33975450
- Overexpression of CD200 is a Stem Cell-Specific Mechanism of Immune Evasion in AML. | Herbrich, S., et al. 2021. J Immunother Cancer. 9: PMID: 34326171
- GAS6 From CD200+ Adipose-Derived Stem Cells Mitigates Colonic Inflammation in a Macrophage-Dependent Manner. | Liang, ZX., et al. 2023. J Crohns Colitis. 17: 289-301. PMID: 36006655
- Specificity of CD200/CD200R pathway in LPS-induced lung inflammation. | Patoine, D., et al. 2022. Front Immunol. 13: 1092126. PMID: 36591265
- Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients. | Khalil, M., et al. 2023. Diagnostics (Basel). 13: PMID: 36673136
- The Use of CD200 in the Differential Diagnosis of B-Cell Lymphoproliferative Disorders. | Al-Zubaidi, HK. and Hughes, SF. 2023. Br J Biomed Sci. 80: 11573. PMID: 37822353
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OX2 Antibody (1.BB.648) | sc-71762 | 200 µg/ml | $322.00 | |||
OX2 Antibody (1.BB.648): m-IgG Fc BP-HRP Bundle | sc-539402 | 200 µg Ab; 10 µg BP | $361.00 | |||
OX2 Antibody (1.BB.648): m-IgG1 BP-HRP Bundle | sc-541468 | 200 µg Ab; 20 µg BP | $361.00 | |||
OX2 Antibody (1.BB.648) FITC | sc-71762 FITC | 200 µg/ml | $336.00 | |||
OX2 Antibody (1.BB.648) PE | sc-71762 PE | 200 µg/ml | $349.00 |