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The gamma-glutamyl cycle involves a series of reactions that are necessary for the synthesis and metabolism of glutathione (GST), which is crucial for regulating amino acid transport. OPLAH [5-oxoprolinase (ATP-hydrolysing)], also known as OPLA, 5-oxo-L-prolinase, 5-Opase or DKFZp434H244OPLA, is an enzyme that plays an important role in the gamma-glutamyl cycle by catalyzing the cleavage of 5-oxo-L-proline to form L-glutamate in a reaction coupled to the hydrolysis of ATP to ADP and inorganic phosphate. OPLAH is a 1,288 amino acid protein that exists as a homodimer and belongs to the oxoprolinase family. Expressed at highest levels in kidney, OPLAH has also been found at lower levels in lung, breast, colon and ovary. The gene encoding OPLAH maps to human chromosome 8, which consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies including Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome and congenital hypothyroidism.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps OPLAH (E-6) | sc-365027 | 200 µg/ml | $316.00 | |||
OPLAH (E-6): m-IgG3 BP-HRP Kit | sc-550415 | 200 µg Ab; 40 µg BP | $354.00 | |||
OPLAH (E-6) peptide neutralisant | sc-365027 P | 100 µg/0.5 ml | $68.00 |