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The ubiquitously expressed sodium/potassium-ATPase (Na+/K+-ATPase) (also designated ATP1A3 antibody, or ATPase Na+/K+ transporting subunit alpha 3 antibody) exists as a oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na+ ions and two K+ ions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na+/K+-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. Multiple isoforms of three subunits, α, β and γ, comprise the Na+/K+-ATPase oligomer. The α subunit contains the binding sites for ATP and the cations; the glycosylated β subunit ensures correct folding and membrane insertion of the α subunits. The small γ subunit co-localizes with the α subunit in nephron segments, where it increases the affinity of Na+/K+-ATPase for ATP. The β subunit, but not the γ subunit, is essential for normal activity of Na+/K+-ATPase.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps alpha 3 Sodium Potassium ATPase/ATP1A3 (F-1) | sc-374050 | 200 µg/ml | $316.00 | |||
alpha 3 Sodium Potassium ATPase/ATP1A3 (F-1): m-IgG3 BP-HRP Kit | sc-550447 | 200 µg Ab; 40 µg BP | $354.00 | |||
alpha 3 Sodium Potassium ATPase/ATP1A3 (F-1) peptide neutralisant | sc-374050 P | 100 µg/0.5 ml | $68.00 |