Anticorps N-WASP (93-W): sc-100964
- L'Anticorps N-WASP (93-W) est un monoclonal de souris IgG2b κ, cité dans 5 publications, fourni en 100 µg/ml
- dirigé contre la N-WASP recombinante d'origine human
- recommandé pour la détection de N-WASP d'origine mouse, rat et human par WB, IP, IF et ELISA
- Voir WASP (B-9): sc-13139 pour d'autres anticorps conjugués N-WASP, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire N-WASP (93-W). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
The Wiskott-Aldrich syndrome (WAS) is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity, and a propensity for lymphoproliferative diseases. The syndrome is the result of a mutation in the gene encoding a proline-rich protein termed WASP. WASP and the related protein neural-WASP (or N-WASP) are downstream effectors of Cdc42. Both WASP and N-WASP are implicated in Actin polymerization and cytoskeletal organization, and N-WASP is also essential for mediating the Cdc42-induced formation of filopodia. WASP is primarily expressed in hematopoietic cells, whereas N-WASP is richest in neural tissues and is also expressed ubiquitously. The effects of Cdc42-stimulated Actin assembly require the interaction of WASP/N-WASP with the Arp2/3 complex, which dramatically enhances polymerization. The WASP and N-WASP proteins characteristically contain a pleckstrin homology (PH) domain, which binds phosphatidyl-inositol bisphosphate (PIP2); a Cdc42-binding domain; and a 70 amino acid conserved verprolin-homology (VPH) domain, which is the Actin-binding region and is critical to the regulation of the Actin cytoskeleton.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps N-WASP (93-W) | sc-100964 | 100 µg/ml | $339.00 |