ACCÈS RAPIDE AUX LIENS
Munc13-4 is a member of the Munc13 family and is a homolog to Munc13-1. Munc13-4 lacks the C1 domain and N-terminal extension that are present in other Munc13 family members. It is a peripheral membrane, GTP-Rab 27a-binding protein. Munc13-4 has a ubiquitous tissue distribution, however, unlike related proteins Munc13-1, -2 and -3, Munc13-4 is mainly expressed outside the nervous system. High expression levels of Munc13-4 have been seen in mucous goblet and alveolar type II cells of the lung, as well as in cytotoxic T lymphocytes and mast cells. Munc13-4 localizes to secretory lysosomes. Overexpression of Munc13-4 enhances degranulation of mast cell secretory lysosomes, suggesting that it positively regulates secretory lysosome fusion and exocytosis. Mutations in Munc13-4 cause familial hemophagocytic lymphohistiocytosis subtype 3.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Munc13-4 (C-12) | sc-271301 | 200 µg/ml | $316.00 | |||
Munc13-4 (C-12): m-IgG Fc BP-HRP Kit | sc-537605 | 200 µg Ab; 10 µg BP | $354.00 | |||
Munc13-4 (C-12): m-IgGκ BP-HRP Kit | sc-534920 | 200 µg Ab; 40 µg BP | $354.00 | |||
Munc13-4 (C-12): m-IgG2a BP-HRP Kit | sc-548064 | 200 µg Ab; 10 µg BP | $354.00 |