Molecular structure of Montelukast Sodium, CAS Number: 151767-02-1
Montelukast Sodium (CAS 151767-02-1)
See product citations (5)
Application:
Montelukast Sodium is a potent and highly selective CysLT1 receptor antagonist, without demonstrated CysLT2 activity
CAS Number:
151767-02-1
Purity:
≥98%
Molecular Weight:
608.17
Molecular Formula:
C35H35ClNO3S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Montelukast Sodium is a potent, selective, anti-inflammatory CysLT1 receptor antagonist (IC50 < 5nM) with no appreciable affect on the CysLT2 receptor. In rat colitis Montelukast Sodium has demonstrated the ability to increase PGE2 (Prostaglandin E2 - sc-201225) production and lower COX-2 expression. Inhibition is competitive with respect to leukotrienes - particularly LTD4, a biologically active mediator that plays an important role in the control of several biochemical pathways involving pulmonary and immune system function.
Montelukast Sodium (CAS 151767-02-1) References
- Characterization of the human cysteinyl leukotriene CysLT1 receptor. | Lynch, KR., et al. 1999. Nature. 399: 789-93. PMID: 10391245
- Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. | Sarau, HM., et al. 1999. Mol Pharmacol. 56: 657-63. PMID: 10462554
- Characterization of the human cysteinyl leukotriene 2 receptor. | Heise, CE., et al. 2000. J Biol Chem. 275: 30531-6. PMID: 10851239
- Acute effects of the cys-leukotriene-1 receptor antagonist, montelukast, on experimental colitis in rats. | Holma, R., et al. 2001. Eur J Pharmacol. 429: 309-18. PMID: 11698051
- The role of leukotrienes in allergic rhinitis. | Peters-Golden, M. and Henderson, WR. 2005. Ann Allergy Asthma Immunol. 94: 609-18; quiz 618-20, 669. PMID: 15984591
- Montelukast sodium-induced hematuria: a case report and literature review of 19 cases in mainland China. | Xie, JX., et al. 2013. Int J Clin Pharmacol Ther. 51: 958-62. PMID: 24131737
- Do Montelukast Sodium and N-Acetylcysteine Have a Nephroprotective Effect on Unilateral Ureteral Obstruction? A Placebo Controlled Trial in a Rat Model. | Sunay, M., et al. 2015. J Urol. 194: 1132-7. PMID: 25776910
- Fabrication of Montelukast sodium loaded filaments and 3D printing transdermal patches onto packaging material. | Azizoğlu, E. and Özer, Ö. 2020. Int J Pharm. 587: 119588. PMID: 32663585
- Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors. | Ma, C. and Wang, J. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33568498
- Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy. | Naqi, SA., et al. 2021. Pak J Med Sci. 37: 362-366. PMID: 33679914
- Fabrication of pure-drug microneedles for delivery of montelukast sodium. | Azizoglu, E., et al. 2022. Drug Deliv Transl Res. 12: 444-458. PMID: 34480297
- Cross-linked Alginate Beads of Montelukast Sodium Coated with Eudragit for Chronotherapy: Statistical Optimization, In vitro and In vivo Evaluation. | Ranjan, OP., et al. 2022. Curr Drug Deliv. 19: 1047-1060. PMID: 35189803
- Effect of Montelukast sodium combined with Budesonide aerosol on airway function and T lymphocytes in asthmatic children. | Jin, W., et al. 2022. Pak J Med Sci. 38: 1265-1270. PMID: 35799724
- Montelukast, a once-daily leukotriene receptor antagonist, in the treatment of chronic asthma: a multicenter, randomized, double-blind trial. Montelukast Clinical Research Study Group. | Reiss, TF., et al. 1998. Arch Intern Med. 158: 1213-20. PMID: 9625400
- Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction. | Leff, JA., et al. 1998. N Engl J Med. 339: 147-52. PMID: 9664090
Inhibitor of:
CYP2B1, Cyp2c29, Cyp2c37, CYP2J11, CYP2J13, CYP2J6, CYP4A12A, CYP4F11, Cyp4f14, Cyp4f15, CYP4F22, CysLT1 Receptor, eotaxin, Fc ε RIβ, Gm885, IgE, IL-18Rβ, LT-β, Mast Cell Protease 10, MrgB2, RSHL3, and Tryptase.Activator of:
ACOXL, Cyp4f13, CysLT2 Receptor, EPX, LTB4DH, LTB4R2, Serglycin, and XYLB.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Montelukast Sodium, 10 mg | sc-202231 | 10 mg | $51.00 | |||
Montelukast Sodium, 25 mg | sc-202231A | 25 mg | $85.00 | |||
Montelukast Sodium, 250 mg | sc-202231B | 250 mg | $161.00 |