ACCÈS RAPIDE AUX LIENS
Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (StAR). StAR is homologous to a family of proteins containing a 200-210 amino acid StAR-related lipid transfer (StART) domain, including StARD3 (also known as MLN64). Amplification of the gene which encodes MLN64 results in overexpression and coamplification with ErbB-2 in breast cancer cell lines. Immunoblot analysis shows expression in most breast cancer cell lines and tissues, as well as in an ovary carcinoma cell line. Immunofluorescence microscopy and mutation analysis shows cytoplasmic expression in condensation sites and perinuclear condensation in breast cancer biopsies. It is suggested that MLN64 acts on late endosome cholesterol traffic, possibly lowering cholesterol by shuttling it to a cytoplasmic receptor site.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps MLN64 (B-2) | sc-390039 | 200 µg/ml | $316.00 | |||
MLN64 (B-2): m-IgG Fc BP-HRP Kit | sc-540746 | 200 µg Ab; 10 µg BP | $354.00 | |||
MLN64 (B-2): m-IgG1 BP-HRP Kit | sc-542344 | 200 µg Ab; 20 µg BP | $354.00 |