MEK kinase-4 Antibody (E-5): sc-166196
- MEK kinase-4 Antibody (E-5) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1531-1607 mapping at the C-terminus of MEK kinase-4 of human origin
- recommended for detection of MEK kinase-4 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG1 BP-HRP is the preferred secondary detection reagent for MEK kinase-4 Antibody (E-5) for WB applications. This reagent is now offered in a bundle with MEK kinase-4 Antibody (E-5) (see ordering information below).
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MEK kinase-4 Antibody (E-5) is a mouse monoclonal IgG1 antibody that detects MEK kinase-4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MEK kinase-4 plays a crucial role in the mitogen-activated protein (MAP) kinase signaling cascade, which is essential for various cellular processes, including proliferation, differentiation, and response to stress. Specifically, MEK kinase-4 is known to activate the c-Jun N-terminal kinase (JNK) pathway, which is involved in regulating apoptosis and cellular responses to stress stimuli. The activation of this pathway is vital for maintaining cellular homeostasis and mediating the effects of growth factors and cytokines. By phosphorylating and activating JNK, MEK kinase-4 contributes to the cellular response to environmental changes, making MEK kinase-4 a key player in both normal physiological processes and pathological conditions such as cancer and neurodegenerative diseases. Anti-MEK kinase-4 antibody (E-5) is an invaluable tool for researchers aiming to explore the intricate signaling networks that govern cell behavior and to investigate the implications of MEK kinase-4 in various disease states.
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MEK kinase-4 Antibody (E-5) References:
- Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation. | Luo, W., et al. 2003. J Biol Chem. 278: 37451-8. PMID: 12878610
- GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. | Chi, H., et al. 2004. EMBO J. 23: 1576-86. PMID: 15044949
- Interferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes. | Halfter, UM., et al. 2005. Biochem J. 388: 17-28. PMID: 15601262
- Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. | Chi, H., et al. 2005. Proc Natl Acad Sci U S A. 102: 3846-51. PMID: 15731347
- CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway. | Aissouni, Y., et al. 2005. Biochem Biophys Res Commun. 338: 808-14. PMID: 16256071
- Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure. | Mizote, I., et al. 2010. J Mol Cell Cardiol. 48: 302-9. PMID: 19850048
- Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy. | Keil, E., et al. 2013. Cell Death Differ. 20: 321-32. PMID: 23059785
- TRAIL/MEKK4/p38/HSP27/Akt survival network is biphasically modulated by the Src/CIN85/c-Cbl complex. | Kim, J., et al. 2013. Cell Signal. 25: 372-9. PMID: 23085457
- HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4). | Sollome, JJ., et al. 2014. Cell Signal. 26: 70-82. PMID: 24036211
- ALV-J inhibits autophagy through the GADD45β/MEKK4/P38MAPK signaling pathway and mediates apoptosis following autophagy. | Liao, Z., et al. 2020. Cell Death Dis. 11: 684. PMID: 32826872
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEK kinase-4 Antibody (E-5) | sc-166196 | 200 µg/ml | $322.00 | |||
MEK kinase-4 Antibody (E-5): m-IgG1 BP-HRP Bundle | sc-542657 | 200 µg Ab; 20 µg BP | $361.00 |