Anticorps MCT4 (G-9): sc-376139
- L'Anticorps MCT4 (G-9) est un monoclonal de souris IgG2b κ, cité dans 7 publications, fourni en 200 µg/ml
- dirigé contre les acides aminés 376-465 situés dans un domaine cytoplasmique C-terminal de MCT4 de human
- recommandé pour la détection de MCT4 d'origine mouse, rat et human par WB, IP, IF, IHC(P) et ELISA
- Voir MCT4 (D-1): sc-376140 pour d'autres anticorps conjugués MCT4, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
- m-IgG Fc BP-HRP, 2b BP-HRP">m-IgG2b BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps MCT4 (G-9) pour les applications WB et IHC(P). Ces réactifs sont désormais proposés en lots avec l'anticorps MCT4 (G-9)(voir les informations de commande ci-dessous).
Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT1 is widely expressed and is the major form of MCT in tumor cells and erythrocytes. MCT2 is highly expressed in liver and testis, while MCT3 and MCT4 are predominantly expressed in skeletal muscle.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps MCT4 (G-9) | sc-376139 | 200 µg/ml | $316.00 | |||
MCT4 (G-9): m-IgG Fc BP-HRP Kit | sc-537972 | 200 µg Ab; 10 µg BP | $354.00 | |||
MCT4 (G-9): m-IgGκ BP-HRP Kit | sc-535468 | 200 µg Ab; 40 µg BP | $354.00 | |||
MCT4 (G-9): m-IgG2b BP-HRP Kit | sc-549904 | 200 µg Ab; 10 µg BP | $354.00 |