Anticorps MASP-3 (CD450): sc-80177

Mannose (or mannan)-binding lectin (MBL), also known as serum mannose-binding protein (MBP), initiates the lectin fork of the innate immune response by binding to the surface of potentially pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component in immune response in that it can directly trigger neutralization of invading microorganisms by an Ab-independent mechanism. In human, three types of MBL-associated serine proteases, MASP-1, MASP-2 and MASP-3, and a truncated form of MASP-2 (small MBL-associated protein, also called sMAP or MAP19) complex with MBL to activate the lectin pathway of the complement system. Activated MASPs subsequently cleave and activate downstream components of the complement pathway. MASP-3 is an alternatively spliced product from the MASP-1 gene. The heavy/A chain is identical to that of MASP-1 but the light/B chain is entirely different. MASP-3 may function to inhibit MASP-2 by competing for MBL binding and inhibiting the activation of MBL-associated MASP-2.

L'anticorps MASP-1/3 préféré est l'Anticorps MASP-1/3 (F-12): sc-166815.