Ly-6D (Lymphocyte antigen 6D), also known as E48 antigen, is a 128 amino acid glycoprotein that is expressed in squamous cell carcinoma cell lines and squamous cell epithelia tissue. Ly-6D contains a signal peptide, 2 theoretical phosphorylation sites and 3 putative myristoylation sites. Upregulation of the gene encoding Ly-6D in head and neck cancers is associated with poor prognosis and high expression of Ly-6D has been linked to enhanced cell migration. Ly-6D is frequently used as a molecular marker for diagnosis and therapy of head-and-neck squamous cell carcinoma (HNSCC). It has been suggested that Ly-6D may regulate the expression levels of certain fucosylated E-selectin ligands and protein FX, a protein that contributes to the last step in the synthesis of GDP-L-fucose, in HNSCC cell lines. This finding is indicative that Ly-6D may regulate tumor cell adhesion in inflamed vessel walls that express E-selectin.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Ly-6D (F-6) | sc-374193 | 200 µg/ml | $316.00 | |||
Ly-6D (F-6): m-IgGκ BP-HRP Kit | sc-535413 | 200 µg Ab; 40 µg BP | $354.00 | |||
Ly-6D (F-6): m-IgG2b BP-HRP Kit | sc-549411 | 200 µg Ab; 10 µg BP | $354.00 | |||
Ly-6D (F-6) peptide neutralisant | sc-374193 P | 100 µg/0.5 ml | $68.00 |