ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
Histone methylation regulates chromatin structure and transcription and maintains an epigenetic state of the cell. Histone methylation is dynamically regulated by histone methylases and demethylases. Lysine-specific histone demethylase 1 (LSD1), also designated BHC110, is a flavin-dependent amine oxidase which catalyzes the removal of one or two methyl groups from the methyl-lysine-4 side chain of Histone H3. The LSD1 protein contains a SWIRM domain, a FAD-binding motif and an amine oxidase domain. Association with CoREST, a SANT domain-containing corepressor, positively regulates LSD1. CoREST mediates the demethylation ability of LSD1 and protects it from proteasomal degradation in vivo. PHF21A (also designated BCH80), a PHD domain-containing protein, inhibits activity of LSD1/CoREST mediated de-methylation. The LSD1 protein also co-localizes with the androgen receptor in human prostate tumor cells and in unaffected prostate cells, stimulating androgen-receptor-dependent transcription.
Alexa Fluor® est une marque déposée de Molecular Probes Inc., OR., USA
LI-COR® et Odyssey® sont marques déposées de LI-COR Biosciences
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps LSD1 (A-2) | sc-398794 | 200 µg/ml | $316.00 | |||
LSD1 (A-2): m-IgG2b BP-HRP Kit | sc-548627 | 200 µg Ab; 10 µg BP | $354.00 | |||
LSD1 (A-2) peptide neutralisant | sc-398794 P | 100 µg/0.5 ml | $68.00 | |||
Anticorps LSD1 (A-2) X | sc-398794 X | 200 µg/0.1 ml | $316.00 |