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Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and α-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including α-2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer′s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
May I know the species reactivity and the isotype control suggested for flow cytometry?
Posée par: Nivetha
Thank you for your question. LRP1 Antibody (8G1) is a mouse monoclonal IgG1 antibody. We recommend it for detection of LRP1 of mouse, rat and human origin by WB, IF, IHC(P) and FCM. The appropriate isotype control for this antibody is normal mouse IgG1: sc-3877.
Feel free to also contact our technical service directly if you have further questions.
Répondue par: Technical Support Europe
Date de publication: 2019-04-12
What's the antigen of this antibody, what motif does it identify? I'd like to know whether it binding with the extracellular segment of LRP1.
Posée par: Aori
Thank you for your question. LRP1 Antibody (8G1) is a mouse monoclonal raised against full length native LRP1 protein of human origin. The antibody specifically recognizes the 515 kDa alpha chain of LRP1, which is mapping within an extracellular domain.
Répondue par: Technical Support
Date de publication: 2019-01-15
I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with LRP1 Antibody (8G1): sc-57353?
Posée par: Trav11
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems.
A complete list of available binding proteins is available on our website here:
If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Rated 5 de
Popular choice for LRP1This antibody, sc-57353: LRP1 (8G1), is a popular choice for Western blot and IHC(P) applications as indicated in 5 current publications featured on the website.
Date de publication: 2016-12-28
Rated 5 de
Positive IHCP data gathered with human frontalPositive IHCP data gathered with human frontal cortex with subcortical white matter -SCBT Publication Review
Date de publication: 2015-04-05
Rated 5 de
WB and ELISA published data with this antibodyWB and ELISA published data with this antibody using mouse RAW 264.7 cell and brain samples -SCBT Publication Review
Date de publication: 2015-03-08
Rated 5 de
Antibody was published for use in WB on human SKAntibody was published for use in WB on human SK-N-SH cells - SCBT Publication Review
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