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LIN-9, also known as TGS, BARA or TGS1, is a 542 amino acid protein that localizes to the nucleoplasm and is a mammalian homolog of the C. elegans Lin-9 protein. Expressed in testis and thymus, LIN-9 functions as a component of the DREAM complex (also known as the LINC complex), which is comprised of several proteins, all of which work in concert to repress cell cycle-dependent genes. LIN-9 specifically acts as a tumor suppressor that associates with Rb and inhibits DNA synthesis, possibly also controlling the expression of genes that are required for the G1/S cell cycle transition. Three isoforms of LIN-9 exist due to alternative splicing events. The gene encoding LIN-9 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps LIN-9 (Mab#1) | sc-130571 | 200 µg/ml | $316.00 |