Lamotrigine isethionate (CAS 113170-86-8)
QUICK LINKS
Lamotrigine isethionate is a water soluble phenyltriazine compound, which functions as an inhibitor of voltage gated sodium channels of presynaptic neurons. Studies indicate that Lamotrigine isethionate blocked sustained repetitive firing of neurons in a dose dependent manner in cultured mouse spinal cords. These studies indicate that Lamotrigine isethionate is effective at suppressing the release of glutamate and aspartate, but have no effect on acetylcholine and GABA release. Lamotrigine isethionate is inactivated by liver microsomes, via hepatic glucuronidation. It is believed that Lamotrigine isethionate modulates the fast voltage-dependent sodium currents in a manner similar to phenytoin and carbamazepine (sc-202518). Futhermore, Lamotrigine isethionate displays a small frequency dependent inhibition of depolarized potentials that result from sodium currents.
Lamotrigine isethionate (CAS 113170-86-8) References
- The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro. | Cunningham, MO. and Jones, RS. 2000. Neuropharmacology. 39: 2139-46. PMID: 10963757
- A novel drug binding site on voltage-gated sodium channels in rat brain. | Riddall, DR., et al. 2006. Mol Pharmacol. 69: 278-87. PMID: 16219909
- Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. | Malik, S., et al. 2006. Expert Rev Neurother. 6: 1609-27. PMID: 17144777
- Lamotrigine is neuroprotective in the energy deficiency model of MPTP intoxicated mice. | Lagrue, E., et al. 2007. Pediatr Res. 62: 14-9. PMID: 17515828
- Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathy. | Papazisis, G., et al. 2008. Int J Neuropsychopharmacol. 11: 321-9. PMID: 17897482
- [Optimisation of a high-efficiency liquid chromatography technique for measuring lamotrigine in human plasma]. | Rivas, N., et al. 2010. Farm Hosp. 34: 85-9. PMID: 20304367
- Antiepileptic action of c-Jun N-terminal kinase (JNK) inhibition in an animal model of temporal lobe epilepsy. | Tai, TY., et al. 2017. Neuroscience. 349: 35-47. PMID: 28237815
- Targeting the central projection of the dural trigeminovascular system for migraine prophylaxis. | Akerman, S. and Romero-Reyes, M. 2019. J Cereb Blood Flow Metab. 39: 704-717. PMID: 28885085
- Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy. | Merseburg, A., et al. 2022. Elife. 11: PMID: 35972069
- Acute effects of lamotrigine (BW430C) in persons with epilepsy. | Binnie, CD., et al. 1986. Epilepsia. 27: 248-54. PMID: 3698937
- Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and rats. | Miller, AA., et al. 1986. Epilepsia. 27: 483-9. PMID: 3757935
- Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. | Leach, MJ., et al. 1986. Epilepsia. 27: 490-7. PMID: 3757936
- Lamotrigine (BW430C), a potential anticonvulsant. Effects on the central nervous system in comparison with phenytoin and diazepam. | Cohen, AF., et al. 1985. Br J Clin Pharmacol. 20: 619-29. PMID: 4091994
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lamotrigine isethionate, 10 mg | sc-218654 | 10 mg | $260.00 |