LAIR-1 Antibody (NKTA255): sc-59281
- LAIR-1 Antibody (NKTA255) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against LAIR-1 from natural killer cell lines B12.100 and AM.25 of human origin
- recommended for detection of LAIR-1 of human origin by WB, IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for biological studies, sc-59281 L,
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LAIR-1 Antibody (NKTA255). This work is in progress.
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LAIR-1 Antibody (NKTA255) is a mouse monoclonal IgG1 antibody that detects leukocyte-associated Ig-like receptor-1 (LAIR-1) in human samples through western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). LAIR-1 is a transmembrane glycoprotein predominantly expressed on human peripheral blood mononuclear leukocytes, playing a crucial role in immune regulation. LAIR-1 functions as an inhibitory receptor on the cell surface, modulating immune responses by recruiting SHP-1, a phosphatase that negatively regulates cell signaling pathways. This interaction maintains the balance of immune activation and inhibition, particularly in T lymphocytes, where LAIR-1 helps establish signaling thresholds essential for T cell receptor (TCR) signaling. Phosphorylation of LAIR-1 at specific tyrosine residues, such as Tyr 233 and Tyr 263, facilitates SHP-1 recruitment and influences downstream signaling events. LAIR-1 engagement on myelomonocytic leukemic cell lines inhibits cell proliferation and induces programmed cell death, while LAIR-1 cross-linking on natural killer (NK) cells significantly dampens cytotoxic activity. Understanding LAIR-1′s role in immune regulation is essential for developing therapeutic strategies targeting immune responses in various diseases.
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LAIR-1 Antibody (NKTA255) References:
- LAIR-1 overexpression inhibits epithelial-mesenchymal transition in osteosarcoma via GLUT1-related energy metabolism. | Zhang, J., et al. 2020. World J Surg Oncol. 18: 136. PMID: 32563267
- Role and mechanism of LAIR-1 in the development of autoimmune diseases, tumors, and malaria: A review. | Guo, N., et al. 2020. Curr Res Transl Med. 68: 119-124. PMID: 32690423
- Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion. | Peng, DH., et al. 2020. Nat Commun. 11: 4520. PMID: 32908154
- LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity. | Helou, DG., et al. 2022. J Allergy Clin Immunol. 149: 223-236.e6. PMID: 34144112
- Blocking LAIR1 signaling in immune cells inhibits tumor development. | Xie, J., et al. 2022. Front Immunol. 13: 996026. PMID: 36211388
- LAIR1, an ITIM-Containing Receptor Involved in Immune Disorders and in Hematological Neoplasms. | Van Laethem, F., et al. 2022. Int J Mol Sci. 23: PMID: 36555775
- LAIR-1 limits macrophage activation in acute inflammatory lung injury. | Helou, DG., et al. 2023. Mucosal Immunol. 16: 788-800. PMID: 37634572
- LAIR-1 agonism as a therapy for acute myeloid leukemia. | Lovewell, RR., et al. 2023. J Clin Invest. 133: PMID: 37966113
- Antitumor Activity of a Novel LAIR1 Antagonist in Combination with Anti-PD1 to Treat Collagen-Rich Solid Tumors. | Rodriguez, BL., et al. 2024. Mol Cancer Ther. 23: 1144-1158. PMID: 38648067
- Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis. | Carvalheiro, T., et al. 2024. J Autoimmun. 146: 103219. PMID: 38696927
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LAIR-1 Antibody (NKTA255) | sc-59281 | 100 µg/ml | $322.00 | |||
LAIR-1 Antibody (NKTA255) FITC | sc-59281 FITC | 100 tests in 2 ml | $336.00 |