L-ficolin, also called ficolin-2, ficolin-B (in mouse and rat), collagen/fibrinogen domain-containing protein 2, serum lectin p35, EBP-37 or hucolin, is a 313 amino acid member of the ficolin lectin family. L-ficolin is a secreted innate immunity pattern recognition molecule expressed in liver and plasma that forms a disulfide-linked homopolymer. This extensive N-terminal disulfide bridge formation can lead to a functional dodecamer polypeptide. L-ficolin binds to DNA ligands expressed by late apoptotic and necrotic cells to increase attachment and engulfment. Variation in L-ficolin concentrations amongst individuals is associated with polymorphisms in the promoter and structural portion of the FCN2 gene. In patient's with Behçet's disease (BD), there exists a significant difference in allele frequency for FCN2 gene single nucleotide polymorphisms (SNPs) within the -557 and -64 promoter sites within HLA-B51-positive and HLA-B51-negative subgroups.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps L-ficolin (005-16-1) | sc-80484 | 200 µg/ml | $316.00 | |||
L-ficolin (005-16-1): m-IgG Fc BP-HRP Kit | sc-539561 | 200 µg Ab; 10 µg BP | $354.00 | |||
L-ficolin (005-16-1): m-IgG1 BP-HRP Kit | sc-541557 | 200 µg Ab; 20 µg BP | $354.00 |