KIF18A Antibody (C-12): sc-390600
- KIF18A Antibody (C-12) is a mouse monoclonal IgG2b κ KIF18A antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 501-519 of KIF18A of human origin
- KIF18A Antibody (C-12) is recommended for detection of KIF18A of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- Anti-KIF18A Antibody (C-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for KIF18A Antibody (C-12) for WB applications. This reagent is now offered in a bundle with KIF18A Antibody (C-12) (see ordering information below).
KIF18A Antibody (C-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects KIF18A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KIF18A antibody (C-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KIF18A, also known as kinesin family member 18A, is a vital protein composed of 898 amino acids that features a kinesin-motor domain, which facilitates ATP-dependent movement along microtubules. This protein plays a critical role in chromosome congression by modulating the dynamics of chromosome movement during cell division, specifically by reducing the amplitude of preanaphase oscillations and slowing the poleward movement during anaphase. The proper functioning of KIF18A is essential for accurate chromosome segregation, which is crucial for maintaining genomic stability and preventing aneuploidy, a condition often associated with cancer. Additionally, KIF18A expression is induced by estrogen, linking KIF18A to hormonal regulation and potentially influencing various cellular processes in response to hormonal changes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KIF18A Antibody (C-12) References:
- MS-KIF18A, new kinesin; structure and cellular expression. | Luboshits, G. and Benayahu, D. 2005. Gene. 351: 19-28. PMID: 15878648
- MS-KIF18A, a kinesin, is associated with estrogen receptor. | Luboshits, G. and Benayahu, D. 2007. J Cell Biochem. 100: 693-702. PMID: 17006958
- The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. | Mayr, MI., et al. 2007. Curr Biol. 17: 488-98. PMID: 17346968
- The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. | Stumpff, J., et al. 2008. Dev Cell. 14: 252-62. PMID: 18267093
- Kinesin-8 molecular motors: putting the brakes on chromosome oscillations. | Gardner, MK., et al. 2008. Trends Cell Biol. 18: 307-10. PMID: 18513970
- New insights on cellular distribution, microtubule interactions and post-translational modifications of MS-KIF18A. | Zusev, M. and Benayahu, D. 2008. J Cell Physiol. 217: 618-25. PMID: 18680169
- The regulation of MS-KIF18A expression and cross talk with estrogen receptor. | Zusev, M. and Benayahu, D. 2009. PLoS One. 4: e6407. PMID: 19636373
- The kinesin-8 Kif18A dampens microtubule plus-end dynamics. | Du, Y., et al. 2010. Curr Biol. 20: 374-80. PMID: 20153196
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KIF18A Antibody (C-12) | sc-390600 | 200 µg/ml | $322.00 | |||
KIF18A Antibody (C-12): m-IgG2b BP-HRP Bundle | sc-548778 | 200 µg Ab; 10 µg BP | $361.00 | |||
KIF18A Antibody (C-12) AC | sc-390600 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KIF18A Antibody (C-12) HRP | sc-390600 HRP | 200 µg/ml | $322.00 | |||
KIF18A Antibody (C-12) FITC | sc-390600 FITC | 200 µg/ml | $336.00 | |||
KIF18A Antibody (C-12) PE | sc-390600 PE | 200 µg/ml | $349.00 | |||
KIF18A Antibody (C-12) Alexa Fluor® 488 | sc-390600 AF488 | 200 µg/ml | $364.00 | |||
KIF18A Antibody (C-12) Alexa Fluor® 546 | sc-390600 AF546 | 200 µg/ml | $364.00 | |||
KIF18A Antibody (C-12) Alexa Fluor® 594 | sc-390600 AF594 | 200 µg/ml | $364.00 | |||
KIF18A Antibody (C-12) Alexa Fluor® 647 | sc-390600 AF647 | 200 µg/ml | $364.00 | |||
KIF18A Antibody (C-12) Alexa Fluor® 680 | sc-390600 AF680 | 200 µg/ml | $364.00 | |||
KIF18A Antibody (C-12) Alexa Fluor® 790 | sc-390600 AF790 | 200 µg/ml | $364.00 | |||
KIF18A (C-12) Neutralizing Peptide | sc-390600 P | 100 µg/0.5 ml | $69.00 |