Molecular structure of JW 55, CAS Number: 664993-53-7
JW 55 (CAS 664993-53-7)
Alternate Names:
N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide
Application:
JW 55 is an inhibitor of the PARP domain and beta-catenin pathway
CAS Number:
664993-53-7
Purity:
≥98%
Molecular Weight:
434.48
Molecular Formula:
C25H26N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
JW 55, a potent inhibitor of tankyrase 1 and tankyrase 2 (TNKS1/2), functions by targeting the PARP domain of these enzymes. By blocking TNKS1/2 activity, JW 55 effectively stabilizes AXIN2, a component of the β-catenin destruction complex. Consequently, this leads to increased degradation of β-catenin, thereby inhibiting the β-catenin signaling pathway. Significantly, JW 55 has its ability to impede canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines, both of which harbor specific genetic mutations in either the APC locus or β-catenin alleles. In vitro studies have that JW 55 reduces the proliferation of SW480 cells.
JW 55 (CAS 664993-53-7) References
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- Validated high-performance liquid chromatography method for the determination of the inhibitor of cancer cell invasion (E)-N-benzyl-6-[2-(3, 4-dihydroxy benzylidene)hydrazinyl]-N-methylpyridine-3-sulfonamide in rat plasma and its application to pharmacokinetic study. | Kim, TK. and Choi, HK. 2017. Biomed Chromatogr. 31: PMID: 27809343
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- GPX8 is transcriptionally regulated by FOXC1 and promotes the growth of gastric cancer cells through activating the Wnt signaling pathway. | Chen, H., et al. 2020. Cancer Cell Int. 20: 596. PMID: 33317536
- ADORA1 is a diagnostic-related biomarker and correlated with immune infiltrates in papillary thyroid carcinoma. | Lin, X., et al. 2021. J Cancer. 12: 3997-4010. PMID: 34093805
- Comprehensive analysis of EMT-related genes and lncRNAs in the prognosis, immunity, and drug treatment of colorectal cancer. | Yang, Y., et al. 2021. J Transl Med. 19: 391. PMID: 34526059
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- Wnt 3a Protects Myocardial Injury in Elderly Acute Myocardial Infarction by Inhibiting Serum Cystatin C/ROS-Induced Mitochondrial Damage. | Shen, J., et al. 2022. Front Physiol. 13: 950960. PMID: 35936906
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- Sp1-Induced SETDB1 Overexpression Transcriptionally Inhibits HPGD in a β-Catenin-Dependent Manner and Promotes the Proliferation and Metastasis of Gastric Cancer. | Fan, Y., et al. 2022. J Gastric Cancer. 22: 319-338. PMID: 36316108
Inhibitor of:
δ-catenin, 2610208M17Rik, 9430069J07Rik, APCDD1, beta-catenin, C1orf80, CELSR1, CELSR3, DAPLE, Dapper1, Dapper3, DIXDC1, Dmp1, EG245190, Enzyme, FAM123A, frizzled-8, HOS, HR, ICAT, IQCK, ITF-1, Kremen-2, LOC666145, LRP5L, MAB-5, Notum, PARP, PCDH11X, POP-1, Prickle4, Pygopus 2, R-Spondin2, R-Spondin3, R-Spondin4, SHISA3, SHKBP1, Soggy-1, SOSTDC1, Tankyrase-2, TBL1XR1, TCF-19, TCF-3, TLE2, TMEM88, Vangl1, WDR27, WFIKKN, WISP-3, Wnt-15, Wnt-6, WTX, Zfp866, and ZNRF3.Activator of:
AIDA, BAR-1, Conductin, Cypt3, Dvl-1, frizzled-7, FRP-3, GPR177, INTU, Kremen-2, LGR4, LIN-31, Six2, Sox-7, USP34, WDR5, Wnt-14, and Wnt-5b.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JW 55, 10 mg | sc-364517 | 10 mg | $172.00 | |||
JW 55, 50 mg | sc-364517A | 50 mg | $726.00 |