JMJD5 (jumonji domain containing 5) is a nuclear protein that is believed to function as a histone lysine demethylase. Belonging to the Jumonji C-domain-containing histone lysine demethylase (JHDM) family, JMJD5 contains one JMJC (Jumonji C) domain. The C. elegans homolog of JMJD5 has been identified as a protein that protects the genome against insertions and deletions. This suggests a potential role for mammalian JMJD5 as a tumor suppressor. Further supporting the role of JMJD5 as a tumor suppressor, the knockdown of JMJD5 expression in mouse fibroblasts can lead to an increased mutation rate and an increased tolerance to MNNG (a DNA methylating agent). This implies that JMJD5 may specifically participate in DNA mismatch repair.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps JMJD5 (G-3) | sc-377440 | 200 µg/ml | $316.00 | |||
JMJD5 (G-3): m-IgG Fc BP-HRP Kit | sc-540717 | 200 µg Ab; 10 µg BP | $354.00 | |||
JMJD5 (G-3): m-IgG1 BP-HRP Kit | sc-542320 | 200 µg Ab; 20 µg BP | $354.00 | |||
JMJD5 (G-3) peptide neutralisant | sc-377440 P | 100 µg/0.5 ml | $68.00 |