JAM-C Antibody (13Y07): sc-80134
- JAM-C Antibody (13Y07) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 100 µg/ml
- raised against the extracellular domain of JAM-C of human origin
- recommended for detection of JAM-C of human origin by WB and IP; non cross-reactive with JAM-A
- also provided azide-free for neutralization, sc-80134 L, 100 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for JAM-C Antibody (13Y07). This work is in progress.
JAM-C Antibody (13Y07) is a mouse monoclonal IgG1 antibody that detects Junctional Adhesion Molecule C (JAM-C) in human samples through western blotting (WB) and immunoprecipitation (IP) applications. JAM-C is a crucial member of the immunoglobulin superfamily, primarily expressed in tight junctions of epithelial and endothelial cells, where JAM-C plays a significant role in maintaining barrier integrity. JAM-C (13Y07) antibody enables detection of a protein essential for cell-to-cell adhesion, facilitating homophilic interactions vital for tight junction organization and leukocyte extravasation regulation. JAM-C interacts with JAM-B, suggesting a functional relationship that may influence lymphocyte trafficking and immune responses. The interaction between JAM-B and JAM-C is particularly important in T cell adhesion, mediating heterotypic interactions that impact inflammation and immune cell migration. Anti-JAM-C antibody (13Y07) helps researchers explore these interaction dynamics and their implications in various physiological and pathological processes, enhancing understanding of immune regulation and barrier function in human tissues.
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JAM-C Antibody (13Y07) References:
- JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration. | Zen, K., et al. 2004. Mol Biol Cell. 15: 3926-37. PMID: 15194813
- Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion. | Lamagna, C., et al. 2005. Mol Biol Cell. 16: 4992-5003. PMID: 16093349
- JAM-C induces endothelial cell permeability through its association and regulation of {beta}3 integrins. | Li, X., et al. 2009. Arterioscler Thromb Vasc Biol. 29: 1200-6. PMID: 19461049
- JAM-C is an apical surface marker for neural stem cells. | Stelzer, S., et al. 2012. Stem Cells Dev. 21: 757-66. PMID: 22114908
- Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. | Arcangeli, ML., et al. 2014. Stem Cells. 32: 1043-54. PMID: 24357068
- Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury. | Wu, D., et al. 2016. Sci Rep. 6: 20545. PMID: 26841848
- Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis. | Hintermann, E., et al. 2016. Cell Adh Migr. 10: 419-33. PMID: 27111582
- Anti-JAM-C therapy eliminates tumor engraftment in a xenograft model of mantle cell lymphoma. | Doñate, C., et al. 2016. J Leukoc Biol. 100: 843-853. PMID: 27256571
- JAM-C Identifies Src Family Kinase-Activated Leukemia-Initiating Cells and Predicts Poor Prognosis in Acute Myeloid Leukemia. | De Grandis, M., et al. 2017. Cancer Res. 77: 6627-6640. PMID: 28972073
- JAM-C Expression as a Biomarker to Predict Outcome of Patients with Acute Myeloid Leukemia-Response. | De Grandis, M., et al. 2018. Cancer Res. 78: 6342-6343. PMID: 30333117
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAM-C Antibody (13Y07) | sc-80134 | 100 µg/ml | $322.00 | |||
JAM-C Antibody (13Y07) L | sc-80134 L | 100 µg/0.1 ml | $322.00 |