Jagged2 Antibody (G-12): sc-518087

Jagged2 Antibody (G-12) is a mouse monoclonal IgG1 antibody that detects Jagged2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Jagged2 is a crucial ligand in the Notch signaling pathway, which plays a significant role in various developmental processes, including cell differentiation and tissue patterning. Jagged2 is primarily located in the cell membrane, where anti-Jagged2 antibody (G-12) can detect interactions with Notch receptors that influence cell fate decisions during embryonic development and in adult tissues. Proper functioning of Jagged2 is vital, as dysregulation of this pathway can lead to developmental disorders and contribute to the progression of certain cancers. Notably, Jagged2 has been implicated in the regulation of hematopoiesis and is expressed in various tissues, including the heart and brain, highlighting its importance in both development and disease. Additionally, aberrant expression of Jagged2 has been associated with several malignancies, making Jagged2 a potential biomarker for cancer diagnosis and therapy. Jagged2 monoclonal antibody (G-12) is an essential tool for researchers investigating the complexities of cell signaling and differentiation in human health and disease.

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Jagged2 Antibody (G-12) References:

1. Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact.  |  Tsai, S., et al. 2000. Blood. 96: 950-7. PMID: 10910909
2. Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis.  |  Pan, Y., et al. 2005. Dev Biol. 286: 472-82. PMID: 16169548
3. Dendritic cell expression of the Notch ligand jagged2 is not essential for Th2 response induction in vivo.  |  Worsley, AG., et al. 2008. Eur J Immunol. 38: 1043-9. PMID: 18350543
4. Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.  |  Kijima, M., et al. 2008. Proc Natl Acad Sci U S A. 105: 7010-5. PMID: 18458347
5. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice.  |  Yang, Y., et al. 2011. J Clin Invest. 121: 1373-85. PMID: 21403400
6. Jagged2 controls the generation of motor neuron and oligodendrocyte progenitors in the ventral spinal cord.  |  Rabadán, MA., et al. 2012. Cell Death Differ. 19: 209-19. PMID: 21720386
7. Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.  |  Kang, H., et al. 2012. Histopathology. 61: 576-86. PMID: 22691042
8. Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis.  |  Xiong, Y., et al. 2016. mBio. 7: PMID: 27302755
9. Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance.  |  Colombo, M., et al. 2020. Haematologica. 105: 1925-1936. PMID: 31582544
10. The effect of bisphenol A on the Notch (Notch2 and Jagged2) signaling pathway in the follicular development of the neonatal rat ovary.  |  Özden Akkaya, Ö., et al. 2024. Biotech Histochem. 99: 238-259. PMID: 39382141

The preferred Jagged2 antibody is Jagged2 Antibody (F-4): sc-515725.