Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
ACCÈS RAPIDE AUX LIENS
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
IL-1RAcP Antibody (D-5) is a high quality monoclonal IL-1RAcP antibody (also designated IL1RAP antibody, IL1R3 antibody, IL-1R3 antibody, or Interleukin 1 receptor AcP antibody) suitable for the detection of the IL-1RAcP protein of mouse, rat and human origin. IL-1RAcP Antibody (D-5) is available as both the non-conjugated anti-IL-1RAcP antibody form, as well as multiple conjugated forms of anti-IL-1RAcP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Interleukin-1 (IL-1) is a key pro-inflammatory cytokine that has diverse actions in the brain as a regulator of host defense responses and a mediator of inflammation. Two major agonists, IL-1α and IL-1β, bind to a single known functional type-1 IL-1 receptor (IL-1RI), which associates with the accessory protein (IL-1RAcP), resulting in signal transduction. IL-1F6, IL-1F8, and IL-1F9 signal through IL-1RAcP to activate NFκB. The membrane bound form of IL-1RAcP (mIL-1RAcP) facilitates signal transduction. Two alternatively spliced isoforms, soluble IL-1RAcP (sIL-1RAcP) and sIL-1RAcP-β, which lack transmembrane and intracellular domains, can inhibit IL-1 signaling. Although both mIL-1RAcP and sIL-1RAcP mRNAs are widely expressed in human tissue, their relative proportions differ significantly in a tissue-specific manner.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences