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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR). Two different receptors exist for IL-13, designated IL-13Rα1 and 2. IL-13Rα1 exists as a heterodimer of IL-13Rα1 and IL-4Rα as a signaling subunit, whereas IL-13Rα2 acts as a decoy receptor for IL-13. Furthermore, TNFα or IL-4 stimulation induces IL-13Rα2 upregulation, while IL-13Rα1 is constitutively expressed. Cell surface localization of IL-13Rα2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13Rα1 expression is predominant in B cells, monocytes and T cells, whereas IL-13Rα2 expression is highest in glioma cells.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can sc-57267: IL-13Rα2 (B-D13) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Posée par: Germaine
Thank you for your question. Yes, sc-57267: IL-13Rα2 (B-D13) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here:
Rated 5 de
Strong Signal, Diverse UsesThis antibody is well-cited for a variety of applications including IF and even IHC. Strong, clear signal with little to no background. Beautiful tissue staining.
Date de publication: 2017-02-09
Rated 5 de
Antibody was used to gather published dataAntibody was used to gather published data in FCM with HeLa, HUT102, Raji, FaDu, and SW579 cell lines
Date de publication: 2015-04-14
Rated 5 de
Positive Flow Cytometry data gathered withPositive Flow Cytometry data gathered with numerous human cell lines tumor lesions and peripheral blood mononuclear cells -SCBT Publication Review
Date de publication: 2015-01-04
Rated 5 de
Produced publishable IF data with human melanomaProduced publishable IF data with human melanoma cell lines - SCBT Publication Review
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