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The Th2 cytokine Interleukin-13 (IL-13) plays a critical role in allergen-induced airway hyper-responsiveness (AHR). Two different receptors exist for IL-13, designated IL-13Rα1 (also designated CD213a1) and IL-13Rα2. IL-13Rα1 exists as a heterodimer of IL-13Rα1 and IL-4Rα as a signaling subunit, whereas IL-13Rα2 acts as a decoy receptor for IL-13. Furthermore, TNFα or IL-4 stimulation induces IL-13Rα2 upregulation, while IL-13Rα1 is constitutively expressed. Cell surface localization of IL-13Rα2 abrogates IL-13 signaling, thus IL-13 induced translocation of the receptor from the cytoplasm provides a mechanism for negative-feedback of IL-13 signaling. IL-13Rα1 expression is predominant in B cells, monocytes and T cells, whereas IL-13Rα2 expression is highest in glioma cells.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps IL-13Rα1 (GM-1E7) | sc-101382 | 200 µg/ml | $316.00 | |||
IL-13Rα1 (GM-1E7): m-IgG Fc BP-HRP Kit | sc-539758 | 200 µg Ab; 10 µg BP | $354.00 | |||
IL-13Rα1 (GM-1E7): m-IgG1 BP-HRP Kit | sc-541688 | 200 µg Ab; 20 µg BP | $354.00 | |||
Anticorps IL-13Rα1 (GM-1E7) FITC | sc-101382 FITC | 200 µg/ml | $330.00 | |||
Anticorps IL-13Rα1 (GM-1E7) PE | sc-101382 PE | 200 µg/ml | $343.00 |