Molecular structure of Hypoxia inducible factor-1α inhibitor, CAS Number: 934593-90-5
Hypoxia inducible factor-1α inhibitor (CAS 934593-90-5)
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Alternate Names:
Hypoxia inducible factor-1α inhibitor is also known as HIF-1 Inhibitor.
Application:
Hypoxia inducible factor-1α inhibitor is an HIF and HIF-1α inhibitor which suppresses expression of downstream target genes.
CAS Number:
934593-90-5
Purity:
≥97%
Molecular Weight:
435.51
Molecular Formula:
C26H29NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hypoxia Inducible Factor-1α Inhibitor is a novel small molecule which inhibits HIF by reducing HIF-1α accumulation and gene transcriptional activity. In a gene reporter assay using human AGS and Hep3B cell lines, Hypoxia Inducible Factor-1α Inhibitor prevented HIF-1 transcriptional activity with IC50 values of 2.6 and 0.7 µM, respectively. Hypoxia Inducible Factor-1α Inhibitor blocks HIF-1α accumulation in Hep3B cells in a concentration and time-dependent manner, with complete inhibition at a concentration of 30 µM within 12 hours. Hypoxia Inducible Factor-1α Inhibitor also significantly suppresses transcription of the HIF-1 target genes VEGF and erythropoietin at 10 µM.
Hypoxia inducible factor-1α inhibitor (CAS 934593-90-5) References
- Quest, chaos and restitution: living with chronic fatigue syndrome/myalgic encephalomyelitis. | Whitehead, LC. 2006. Soc Sci Med. 62: 2236-45. PMID: 16236413
- Toward a trajectory of identity reconstruction in chronic fatigue syndrome/myalgic encephalomyelitis: a longitudinal qualitative study. | Whitehead, L. 2006. Int J Nurs Stud. 43: 1023-31. PMID: 16527282
- Ornithinimicrobium pekingense sp. nov., isolated from activated sludge. | Liu, XY., et al. 2008. Int J Syst Evol Microbiol. 58: 116-9. PMID: 18175694
- LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line. | Lee, K., et al. 2010. Biochem Pharmacol. 80: 982-9. PMID: 20599784
Inhibitor of:
c-IAP 1, CUL-7, H1T2, HAS1, HIF-1 alpha, LOC645188, Sox-14, TIF1α, TRBV3, VHL, and ZBRK1.Activator of:
CCL28, EG434727, EMILIN-1, Emt, ET, GATA-1, GOLGA6A-D, Hemoglobin δ, NAG, POLR2E, RV2623 Dormancy Regulon, and Trap1a.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hypoxia inducible factor-1α inhibitor, 1 mg | sc-205346 | 1 mg | $33.00 | |||
Hypoxia inducible factor-1α inhibitor, 5 mg | sc-205346A | 5 mg | $114.00 | |||
Hypoxia inducible factor-1α inhibitor, 10 mg | sc-205346B | 10 mg | $194.00 | |||
Hypoxia inducible factor-1α inhibitor, 25 mg | sc-205346C | 25 mg | $411.00 |