Anticorps HSV-2 gE Envelope Protein (6F10): sc-56990

Two serotypes of the herpes simplex virus, HSV-1 (also known as type 1 or oral) and HSV-2 (type 2 or genital), can establish lifelong latent infections within sensory ganglia. HSV-1 usually establishes latency in the trigeminal ganglion, a collection of nerve cells near the ear. From there, it tends to recur on the lower lip or face. HSV-2 usually resides in the sacral ganglion at the base of the spine. From there, it reiterates in the genital area. When no symptoms are present, HSV lies dormant in the bodies of the nerve cells. During an outbreak, though, it replicates within axons near the skin. Once the outbreak subsides, the virus then retreats along the nerve until it remains only in the nerve body. Dormancy of the virus within the nerve bodies contributes to its difficulty of treatment. There is currently no known cure or vaccine for HSV. The envelope of HSV consists of glycoproteins derived from the viral genome. The envelope is derived from portions of host cell membranes. Envelope proteins are embedded into the membranous viral envelope to allow host cell recogntion through the identification and binding of host cell receptor sites. Glycoprotein E (HSV-2 gE Envelope Protein) may contribute to viral entry.

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Anticorps HSV-2 gE Envelope Protein (6F10) Références:

1. La protéine ICP34.5 du HSV-2 module le traitement des glycoprotéines du virus de l'herpès simplex.  |  Chatterjee, S., et al. 2009. Arch Virol. 154: 661-3. PMID: 19267180
2. Les antigènes gD de la protéine d'enveloppe du virus de l'herpès simplex, dérivés d'Escherichia coli, mais pas les antigènes gC, protègent les souris contre un défi mortel avec le HSV-1 et le HSV-2.  |  Bröker, M., et al. 1990. Med Microbiol Immunol. 179: 145-59. PMID: 2169577
3. La glycoprotéine J du HSV-2 favorise l'expression des protéines virales et la propagation du virus.  |  Liu, Y., et al. 2018. Virology. 525: 83-95. PMID: 30248525
4. La régulation par pUL21 de l'activité kinase de pUs3 influence la nature de la déformation de l'enveloppe nucléaire par le complexe d'évacuation nucléaire du HSV-2.  |  Muradov, JH., et al. 2021. PLoS Pathog. 17: e1009679. PMID: 34424922

L'anticorps HSV-2 gE Envelope Protein préféré est l'Anticorps HSV-2 gE Envelope Protein (101): sc-52861.