Anticorps HPRT (F-12): sc-373979
- L'Anticorps HPRT (F-12) est un monoclonal de souris IgG2b (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre les acides aminés 1-218 correspondant à la séquence totale de HPRT d'origine human
- recommandé pour la détection de HPRT d'origine mouse, rat et human par WB, IP, IF et ELISA
- 2b BP-HRP">m-IgG2b BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps HPRT (F-12) pour les applications WB. Ces réactifs sont désormais proposés en lots avec l'anticorps HPRT (F-12)(voir les informations relatives à la commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
HPRT (hypoxanthine phosphoribosyltransferase 1), also known as HGPRT or HPRT1, is a 218 amino acid cytoplasmic protein that belongs to the purine/pyrimidine phosphoribosyltransferase family. Involved in purine metabolism, HPRT functions as a purine salvage enzyme that catalyzes the conversion of hypoxathine and guanine to their respective mononucleotides (inosine monophosphate and guanosine monophosphate, respectively). HPRT exists as a homotetramer that can bind two magnesium ions as cofactors. Defects in the gene encoding HPRT are the cause of gout and Lesch-Nyhan syndrome (LNS), both of which are characterized by a partial or complete lack of NPRT enzymatic activity. While a partial loss of HPRT enzymatic activity results in a buildup of uric acid (gout), a total loss of enzymatic activity results in hyperuricaemia, mental retardation, choreoathetosis and compulsive self-mutilation, all of which are symptoms associated with LNS. The severity of these diseases suggests an essential role for HPRT in purine metabolism.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps HPRT (F-12) | sc-373979 | 200 µg/ml | $316.00 | |||
HPRT (F-12): m-IgGκ BP-HRP Kit | sc-535357 | 200 µg Ab; 40 µg BP | $354.00 | |||
HPRT (F-12): m-IgG2b BP-HRP Kit | sc-549402 | 200 µg Ab; 10 µg BP | $354.00 |