The condensin complex plays a role in the resolution and segregation of sister chromatids during mitosis and some aspects of mitotic chromosome assembly. Cdc2 phosphorylation of the complex leads to its activation and its association with chromosome arms and condensation. Condensin complexes are heteropentamers comprised of two SMC (structural maintenance of chromosomes) subunits and three non-SMC subunits. The SMC family includes SMC1 (also known as SMC1α and SCMB), which associates with SMC3 (also known as hCAP and Bamacan); SMC2 (also known as hCAP-E), which associates with SMC4 (also known as hCAP-C); and SMC5, which associates with SMC6. Non-SMC subunits help regulate the complex and include hCAP-D2, hCAP-H and hCAP-G. The C-terminus of hCAP-D2 interacts with Histones H1 and H3 through their histone tails. A loss of hCAP-D2 can lead to the disorganization of chromatid axes, misalignment of sister chromatids during metaphase and delayed entry into anaphase.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps hCAP-D2 (D-3) | sc-166878 | 200 µg/ml | $316.00 | |||
hCAP-D2 (D-3): m-IgG Fc BP-HRP Kit | sc-537539 | 200 µg Ab; 10 µg BP | $354.00 | |||
hCAP-D2 (D-3): m-IgGκ BP-HRP Kit | sc-534837 | 200 µg Ab; 40 µg BP | $354.00 | |||
hCAP-D2 (D-3): m-IgG1 BP-HRP Kit | sc-545217 | 200 µg Ab; 20 µg BP | $354.00 |