Glyburide-d11 (CAS 1189985-02-1)

État Physique :

Solid

Solubilité :

Soluble in DMSO, methanol, and ethanol (5 mg/ml(unlabeled)).

Stockage :

Store at -20° C

Point de fusion :

166-168° C (lit.)

Point d'Ébullition :

708.87° C (Predicted,unlabeled)

Densité :

1.39 g/cm³ (Predicted)

Indice de Réfraction :

n²⁰_D 1.62 (Predicted)

IC50 :

Recombinant CFTR Cl- channels: IC₅₀ = 20 µM(unlabeled); K+ATP channel: IC₅₀ = 1.1 nM (rat,unlabeled); Rattus norvegicus: IC₅₀ = 1.6 nM(unlabeled); Malate dehydrogenase mitochondrial: IC₅₀ = 3 nM (Sus scrofa,unlabeled); Sulfonylurea receptor 1: IC₅₀ = 4.3 nM (human,unlabeled); Beta-lactamase: IC₅₀ = 5 nM (Escherichia coli K-12,unlabeled)

Données Ki :

Potassium channel, inwardly rectifying, subfamily J, member 11: K_i= 0.61 nM (rat,unlabeled); Sulfonylurea receptor 2: K_i= 0.61 nM (rat,unlabeled); Voltage-gated potassium channel subunit Kv4.3: K_i= 0.61 nM (human,unlabeled); Potassium channel, inwardly rectifying, subfamily J, member 8: K_i= 0.61 nM (rat,unlabeled)

Valeurs pK :

pK_a: 5.11 (Predicted)(unlabeled)

RTECS :

YS4725200

PubChem CID :

Indice Merck :

14: 4478

Numéro MDL :

MFCD09840669

Numéro EC :

233-570-6(unlabeled)

Registre Beilstein :

2230085(unlabeled)

SMILES :

[2H]C1(C(C(C(C(C1([2H])[2H])([2H])[2H])([2H])NC(=O)NS(=O)(=O)C2=CC=C(C=C2)CCNC(=O)C3=C(C=CC(=C3)Cl)OC)([2H])[2H])([2H])[2H])[2H]