GATA3 Antibody (C-11): sc-514427
- GATA3 Antibody (C-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 167-214 of GATA-3 of human origin
- recommended for detection of GATA-3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for ChIP application (sc-514427 X, 200 µg/0.1 ml)
- See GATA3 (HG3-31): sc-268 for GATA3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GATA3 Antibody (C-11) for WB and IHC(P) applications. These reagents are now offered in bundles with GATA3 Antibody (C-11) (see ordering information below).
GATA-3 Antibody (C-11) is a mouse monoclonal IgG1 antibody that detects GATA-3 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). GATA-3 plays a crucial role in the development and function of T lymphocytes, making GATA-3 essential for the immune response and the differentiation of T helper cells. GATA-3 is primarily located in the nucleus, where GATA-3 regulates the expression of genes involved in T cell development and function. GATA-3′s nuclear localization enables interaction with specific DNA sequences, thereby influencing the transcription of target genes vital for T cell lineage commitment and function. GATA-3 interacts with other proteins such as TCF-1 and Runx1, which further underscores GATA-3′s role in the complex regulatory networks governing T cell biology. Anti-GATA-3 antibody (C-11) serves as an invaluable tool for researchers studying T cell development, immune responses, and related pathologies, providing insights into the molecular mechanisms underlying these processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GATA3 Antibody (C-11) References:
- GATA-3 transduces survival signals in osteoblasts through upregulation of bcl-x(L) gene expression. | Chen, RM., et al. 2010. J Bone Miner Res. 25: 2193-204. PMID: 20499358
- GATA-3 regulates contact hyperresponsiveness in a murine model of allergic dermatitis. | Tamauchi, H., et al. 2012. Immunobiology. 217: 446-54. PMID: 22112437
- GATA-3 regulates the self-renewal of long-term hematopoietic stem cells. | Frelin, C., et al. 2013. Nat Immunol. 14: 1037-44. PMID: 23974957
- GATA-3 expression in trophoblastic tissues: an immunohistochemical study of 445 cases, including diagnostic utility. | Banet, N., et al. 2015. Am J Surg Pathol. 39: 101-8. PMID: 25188865
- Similarity of GATA-3 Expression between Rat and Human Mammary Glands. | Kinoshita, Y., et al. 2014. J Toxicol Pathol. 27: 159-62. PMID: 25352719
- Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells. | Huang, P., et al. 2016. Mediators Inflamm. 2016: 1701059. PMID: 27833268
- GATA-3-specific DNAzyme - A novel approach for stratified asthma therapy. | Garn, H. and Renz, H. 2017. Eur J Immunol. 47: 22-30. PMID: 27910098
- Usefulness of GATA-3 as a marker of seminal epithelium in prostate biopsies. | Ortiz-Rey, JA., et al. 2017. Actas Urol Esp. 41: 577-583. PMID: 28461097
- Expression of GATA-3 in Testicular and Gynecologic Mesothelial Neoplastic and Non-neoplastic Tissues. | Ronaghy, A., et al. 2018. Int J Gynecol Pathol. 37: 284-289. PMID: 28582342
- Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes. | Al-Mansoori, L., et al. 2020. Cell Signal. 75: 109735. PMID: 32795510
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GATA3 Antibody (C-11) | sc-514427 | 200 µg/ml | $322.00 | |||
GATA3 Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-538644 | 200 µg Ab; 10 µg BP | $361.00 | |||
GATA3 Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-536293 | 200 µg Ab; 40 µg BP | $361.00 | |||
GATA3 Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-545808 | 200 µg Ab; 20 µg BP | $361.00 | |||
GATA3 Antibody (C-11) X | sc-514427 X | 200 µg/0.1 ml | $322.00 |