G_{α i-2} Antibody (5C11): sc-80007

Gα i-2 Antibody (5C11) is a mouse monoclonal IgG1 kappa light chain antibody designed to target the full-length Gα i-2 protein of rat origin, also known as GNAI2. Gα i-2 mouse monoclonal antibody (5C11) detects Gα i-2 across a broad range of species, including mouse, rat, human, and others, making it an invaluable tool for applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Gα i-2 is a critical component of heterotrimeric G proteins, which are essential for transmitting signals from cell surface receptors to intracellular effectors, thereby playing a pivotal role in various cellular processes. Located primarily at the plasma membrane and within the cytoplasm, Gα i-2 facilitates the regulation of intracellular signaling pathways by binding and hydrolyzing GTP, which in turn modulates the activity of downstream effectors like adenylyl cyclase. This regulation is crucial for maintaining cellular homeostasis and enabling appropriate responses to extracellular stimuli such as hormones, neurotransmitters, and other signaling molecules. The precise localization of Gα i-2 within the cell ensures efficient signal transduction and proper cellular responses, highlighting its importance in processes like the inhibition of adenylyl cyclase activity, which leads to decreased cyclic AMP levels and the modulation of ion channels, including the opening of atrial potassium channels. By providing robust and reliable detection of Gα i-2, anti-Gα i-2 antibody (5C11) supports advanced research into G protein-coupled receptor signaling pathways, facilitating a deeper understanding of the molecular mechanisms underlying diverse physiological and pathological events. Gα i-2 monoclonal antibody (5C11) is an essential reagent for scientists investigating the intricate dynamics of cellular communication and signal transduction.

The preferred G_{α i-2} antibody is G_{α i-2} Antibody (L5): sc-13534.