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The mammalian FXYD family maintains Na+ and K+ gradients between the intracellular and extracellular milieus of cells in processes such as renal Na+-reabsorption, muscle contraction and neuronal excitability. FXYDs are single-span membrane proteins that share a 35 amino acid signature domain, beginning with the sequence PFXYD and containing seven invariant and six conserved amino acids. Members of the FXYD family include FXYD1 (PLM, phospholemman), FXYD2 (the γ subunit of the Na/K-ATPase), FXYD3 (Mat8, mammary tumor protein), FXYD4 (CHIF) and FXYD5 (RIC). FXYD3, a 67 amino acid protein, may act as a chloride channel or as a chloride channel regulator. It is expressed in a subset of human breast tumors and shows partial homology to FXYD1. FXYD3 has a putative 20 amino acid leader sequence and a putative transmembrane domain (with two cysteine residues). It contains no consensus phosphorylation sites in the cytoplasmic domain.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps FXYD3 (A-3) | sc-271629 | 200 µg/ml | $316.00 | |||
FXYD3 (A-3): m-IgG3 BP-HRP Kit | sc-550407 | 200 µg Ab; 40 µg BP | $354.00 | |||
FXYD3 (A-3) peptide neutralisant | sc-271629 P | 100 µg/0.5 ml | $68.00 |