Date published: 2026-4-23

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Fmoc-Ile-OH (CAS 71989-23-6)

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Alternate Names:
N-(9-Fluorenylmethoxycarbonyl)-L-isoleucine; Fmoc-L-isoleucine
Application:
Fmoc-Ile-OH is an Fmoc-protected form of Isoleucine
CAS Number:
71989-23-6
Molecular Weight:
353.41
Molecular Formula:
C21H23NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fmoc-Ile-OH is a chemical compound that functions as a building block in peptide synthesis. It plays a role in the solid-phase peptide synthesis process, where it is used to introduce the amino acid isoleucine into the peptide chain. Fmoc-Ile-Oh acts as a protecting group for the amino group of isoleucine, allowing for selective deprotection and subsequent coupling reactions during peptide assembly. Through its mechanism of action, Fmoc-Ile-OH facilitates the stepwise elongation of the peptide chain by enabling the controlled addition of isoleucine at specific positions. Fmoc-Ile-Oh interacts at the molecular level, participating in the formation of peptide bonds.


Fmoc-Ile-OH (CAS 71989-23-6) References

  1. Screening of Self-Assembling of Collagen IV Fragments into Stable Structures Potentially Useful in Regenerative Medicine.  |  Kolasa, M., et al. 2021. Int J Mol Sci. 22: PMID: 34948383
  2. Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H1 Receptor.  |  Kok, ZY., et al. 2022. J Med Chem. 65: 8258-8288. PMID: 35734860
  3. Synthesis and Application of a Clickable Epoxomicin-Based Probe for Proteasome Activity Analysis.  |  Salazar-Chaparro, AF., et al. 2022. Curr Protoc. 2: e490. PMID: 35849029
  4. Metal-Ion Interactions with Dodecapeptide Fragments of Human Cationic Antimicrobial Protein LL-37 [hCAP(134-170)].  |  Brzeski, J., et al. 2022. J Phys Chem B. 126: 6911-6921. PMID: 36047059
  5. Relations between Structure and Zn(II) Binding Affinity Shed Light on the Mechanisms of Rad50 Hook Domain Functioning and Its Phosphorylation.  |  Tran, JB., et al. 2022. Int J Mol Sci. 23: PMID: 36232441
  6. Solid-phase synthesis and pathological evaluation of pyroglutamate amyloid-β3-42 peptide.  |  Cho, I., et al. 2023. Sci Rep. 13: 505. PMID: 36627316
  7. Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis.  |  Personne, H., et al. 2023. ACS Omega. 8: 5050-5056. PMID: 36777595
  8. Antimicrobial Peptides Designed against the Ω-Loop of Class A β-Lactamases to Potentiate the Efficacy of β-Lactam Antibiotics.  |  Biswal, S., et al. 2023. Antibiotics (Basel). 12: PMID: 36978420
  9. Coating Methods of Carbon Nonwovens with Cross-Linked Hyaluronic Acid and Its Conjugates with BMP Fragments.  |  Magdziarz, S., et al. 2023. Polymers (Basel). 15: PMID: 36987331
  10. Improved LC-MS identification of short homologous peptides using sequence-specific retention time predictors.  |  Hollebrands, B., et al. 2023. Anal Bioanal Chem. 415: 2715-2726. PMID: 37000211
  11. Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability.  |  Al Ayed, K., et al. 2023. ACS Infect Dis. 9: 739-748. PMID: 37000899
  12. Food-inspired peptides from spinach Rubisco endowed with antioxidant, antinociceptive and anti-inflammatory properties.  |  Marinaccio, L., et al. 2023. Food Chem X. 18: 100640. PMID: 37008720

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fmoc-Ile-OH, 50 g

sc-235190
50 g
$114.00