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The Factor H gene family is a multidomain, multifunctional protein family whose individual members are defined by conserved structural elements, which display diverse yet often overlapping functions. These proteins share a common structural motif, the short consensus repeat (SCR), which is structurally conserved among related genes and between phylogenetically divergent species. The human complement Factor H (FH, CFH, HUS, b-1H) gene encodes a 1213 amino acid serum glycoprotein which is arranged into 20 SCRs, each approximately 60 amino acids long, and an 18-residue leader sequence. Factor H controls the function of the alternative complement pathway and acts as a cofactor with Factor I (C3b inactivator). In addition, Factor H has functional activity outside of the complement system, where it can bind to the cellular integrin receptor (CD11b/CD18), interact with cell surface glycosaminoglycans and associate with the surface of certain pathogenic microorganisms. Deficiencies in Factor H is a common characteristic of acute renal disease.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Factor H (D-8) | sc-398245 | 200 µg/ml | $316.00 | |||
Factor H (D-8): m-IgG Fc BP-HRP Kit | sc-538404 | 200 µg Ab; 10 µg BP | $354.00 | |||
Factor H (D-8): m-IgGκ BP-HRP Kit | sc-536013 | 200 µg Ab; 40 µg BP | $354.00 | |||
Factor H (D-8): m-IgG1 BP-HRP Kit | sc-545685 | 200 µg Ab; 20 µg BP | $354.00 | |||
Factor H (D-8) peptide neutralisant | sc-398245 P | 100 µg/0.5 ml | $68.00 |