The Ets-1 family of transcription factors has a conserved DNA binding domain through which it plays an important role in cellular proliferation, differentiation, tematopoiesis and angiogenesis. This domain, also known as the Ets domain, binds to DNA sequences containing the consensus sequence 5′-WGGA-3′, which is known as the Ets-binding domain. Elf-4, also known as myeloid Elf-1-like factor, ELF4 or MEF, is a 663 amino acid member of the Ets-1 family. Localized to the nucleus, Elf-4 is highly expressed in placenta and myeloid leukemia cells, with lower levels of expression lung, heart, thymus, spleen, colon, ovary and peripheral blood lymphocytes. Functioning primarily to activate the promoters of hematopoietic growth factor genes, such as GM-CSF, IL-3 and IL-8, Elf-4 has also been shown to activate the Perforin 1 promoter in natural killer (NK) cells, suggesting a possible role in tumorigenesis.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Elf-4 (F-11) | sc-390689 | 200 µg/ml | $316.00 | |||
Elf-4 (F-11): m-IgGκ BP-HRP Kit | sc-535638 | 200 µg Ab; 40 µg BP | $354.00 | |||
Anticorps Elf-4 (F-11) X | sc-390689 X | 200 µg/0.1 ml | $316.00 |