EB 1089 (CAS 134404-52-7)
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EB 1089 is a VDR (vitamin D receptor) agonist, serving as an analog of 1,25 dihydroxyvitamin D. Its role as an agonist allows it to effectively reverse hypercalcemia and inhibit PTH-rP (parathyroid hormone-related peptide, PTHRP) in vitro. Notably, in studies using a squamous cancer cell line, EB 1089 demonstrated the ability to reverse hypercalcemia. Moreover, it displayed downregulation of PTHRP expression in a prostate cancer cell line, C4-2, and promoted anchorage-independent cell growth in vitro. Furthermore, EB 1089 has exhibited inhibitory effects on the proliferation of HEp-2 cell lines, with p57 playing a significant role in this inhibition. Additionally, it acts as a mitogen for neonatal rat lung fibroblasts. Its activation of the vitamin D receptor (VDR) regulates the expression of genes associated with cell growth and differentiation. Moreover, EB 1089 interacts with various proteins, including nuclear factor-kappa B (NF-kB), peroxisome proliferator-activated receptor gamma (PPAR-γ), and cyclic AMP response element binding protein (CREB). These interactions are believed to underlie the anti-inflammatory, anti-apoptotic, and anti-proliferative effects exhibited by EB 1089 in vitro.
EB 1089 (CAS 134404-52-7) References
- Reversal of hypercalcemia with the vitamin D analogue EB1089 in a human model of squamous cancer. | El Abdaimi, K., et al. 1999. Cancer Res. 59: 3325-8. PMID: 10416587
- Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation. | Hansen, CM., et al. 2000. Curr Pharm Des. 6: 803-28. PMID: 10828309
- The vitamin D3 analog EB 1089 enhances the antiproliferative and apoptotic effects of adriamycin in MCF-7 breast tumor cells. | Sundaram, S., et al. 2000. Breast Cancer Res Treat. 63: 1-10. PMID: 11079153
- Vitamin D(3) analogs (MC 1288, KH 1060, EB 1089, GS 1558, and CB 1093): studies on their mechanism of action. | Mäenpää, PH., et al. 2001. Steroids. 66: 223-5. PMID: 11179729
- The G gamma / T-15 transgenic mouse model of androgen-independent prostate cancer: target cells of carcinogenesis and the effect of the vitamin D analogue EB 1089. | Perez-Stable, CM., et al. 2002. Cancer Epidemiol Biomarkers Prev. 11: 555-63. PMID: 12050097
- The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice. | Sundaram, S., et al. 2003. Clin Cancer Res. 9: 2350-6. PMID: 12796405
- Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery. | Demasters, G., et al. 2006. Mol Cancer Ther. 5: 2786-97. PMID: 17121925
- The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung. | Ormerod, AK., et al. 2008. Exp Lung Res. 34: 155-82. PMID: 18432454
- Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57. | Lu, L., et al. 2008. Mol Cancer Ther. 7: 1268-74. PMID: 18483314
- EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells. | Bhatia, V., et al. 2009. Mol Cancer Ther. 8: 1787-98. PMID: 19584236
- EB 1089, a calcitriol analogue, decreases fetal calcium content when injected into pregnant rats. | Davicco, MJ., et al. 1995. Exp Physiol. 80: 449-56. PMID: 7640009
- Comparative effects of 1,25-dihydroxyvitamin D3 and EB 1089 on mouse renal and intestinal 25-hydroxyvitamin D3-24-hydroxylase. | Roy, S., et al. 1995. J Bone Miner Res. 10: 1951-9. PMID: 8619376
- EB 1089, a novel vitamin D analog with strong antiproliferative and differentiation-inducing effects on target cells. | Hansen, CM. and Mäenpää, PH. 1997. Biochem Pharmacol. 54: 1173-9. PMID: 9416968
- EB 1089, a novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cells. | Mathiasen, IS., et al. 1993. J Steroid Biochem Mol Biol. 46: 365-71. PMID: 9831485
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EB 1089, 500 µg | sc-358831A | 500 µg | $161.00 | |||
EB 1089, 1 mg | sc-358831 | 1 mg | $212.00 | |||
EB 1089, 5 mg | sc-358831B | 5 mg | $941.00 |